NXT1

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.[5][6][7]

NXT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JKG, 1JN5, 4WYK
Identifiers
Aliases	NXT1, MTR2, P15, nuclear transport factor 2 like export factor 1
External IDs	OMIM: 605811 MGI: 1929619 HomoloGene: 8301 GeneCards: NXT1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,350,791 bp[1] End 23,354,771 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 148,672,601 bp[2] End 148,676,027 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Ran GTPase binding • GO:0001948 protein binding Cellular component • cell nucleus • nuclear speck • nuclear pore • nucleoplasm • cytoplasm • cytosol • nuclear pore central transport channel Biological process • protein export from nucleus • protein transport • RNA export from nucleus • mRNA export from nucleus • protein import into nucleus • nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29107	56488
Ensembl	ENSG00000132661	ENSMUSG00000036992
UniProt	Q9UKK6	Q9QZV9
RefSeq (mRNA)	NM_013248	NM_001110159 NM_019761
RefSeq (protein)	NP_037380	NP_001103629 NP_062735
Location (UCSC)	Chr 20: 23.35 – 23.35 Mb	Chr 2: 148.67 – 148.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000132661 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036992 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Black BE, Levesque L, Holaska JM, Wood TC, Paschal BM (Jan 2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol Cell Biol. 19 (12): 8616–24. doi:10.1128/MCB.19.12.8616. PMC 84993. PMID 10567585.
6. Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjold ML (Mar 2001). "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells". Mol Cell Biol. 21 (7): 2545–54. doi:10.1128/MCB.21.7.2545-2554.2001. PMC 86886. PMID 11259602.
7. "Entrez Gene: NXT1 NTF2-like export factor 1".

Further reading

• Katahira J, Strässer K, Podtelejnikov A, et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–609. doi:10.1093/emboj/18.9.2593. PMC 1171339. PMID 10228171.
• Ossareh-Nazari B, Maison C, Black BE, et al. (2000). "RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro". Mol. Cell. Biol. 20 (13): 4562–71. doi:10.1128/MCB.20.13.4562-4571.2000. PMC 85847. PMID 10848583.
• Herold A, Suyama M, Rodrigues JP, et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Mol. Cell. Biol. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.
• Black BE, Holaska JM, Lévesque L, et al. (2001). "NXT1 is necessary for the terminal step of Crm1-mediated nuclear export". J. Cell Biol. 152 (1): 141–55. doi:10.1083/jcb.152.1.141. PMC 2193657. PMID 11149927.
• Jun L, Frints S, Duhamel H, et al. (2002). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Curr. Biol. 11 (18): 1381–91. doi:10.1016/S0960-9822(01)00419-5. PMID 11566096. S2CID 18567485.
• Fribourg S, Braun IC, Izaurralde E, Conti E (2001). "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor". Mol. Cell. 8 (3): 645–56. doi:10.1016/S1097-2765(01)00348-3. PMID 11583626.
• Wiegand HL, Coburn GA, Zeng Y, et al. (2002). "Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes". Mol. Cell. Biol. 22 (1): 245–56. doi:10.1128/MCB.22.1.245-256.2002. PMC 134221. PMID 11739738.
• Katahira J, Straesser K, Saiwaki T, et al. (2002). "Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling". J. Biol. Chem. 277 (11): 9242–6. doi:10.1074/jbc.M110007200. PMID 11756420.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.