Nancy Carrasco

Nancy Carrasco is the C.N.H. Long Professor of Cellular and Molecular Physiology at Yale University and on the faculty in physiology and pharmacology at Vanderbilt University.[1] Carrasco has conducted research across the fields of biochemistry, biophysics, and physiology.[2] Her research on sodium/iodide symporter (NIS) has become an important aspect in treating thyroid cancers.[3] Carrasco is a leader in the study of membrane transporters and her work on NIS has become vital for the evaluation, diagnosis, and treatment of thyroid disorders[4] and breast cancers.[1]

Nancy Carrasco
NationalityMexican
Alma materSchool of Chemistry, UNAM
School of Medicine, UNAM
Spouse(s)Samuel Zyman
Children1
AwardsPew Award, (1989)

Beckman Young Investigators Award, (1991)

Maria Sibylla Merian Award (1998)

Marshall S. Horwitz Faculty Prize for Research Excellence, (2009)

Light of Life Award, (2010)

Member of the National Academy of Sciences (2015)

Sidney H. Ingbar Distinguished Lecturer, American Thyroid Association (2016)
Scientific career
FieldsMolecular physiology
Pharmacology

Biophysics

Cell physiology
InstitutionsYale University
Vanderbilt University
Albert Einstein College of Medicine

Early life and Education

Carrasco was born in Mexico City, Mexico. She earned her M.D. and M.S. degree in biochemistry from the School of Medicine and the School of Chemistry of the National Autonomous University of Mexico in 1980 and 1981 respectively.[5] Following graduation, she became a postdoctoral researcher at the Roche Institute of Molecular Biology.[2] During her postdoctoral research she worked with mentor Howard Ronald Kaback.[6] While Carrasco worked there, the Kaback team discovered the use of lactose permease to find the presence of E. coli which forms into the Proteliposomes.[6]

Career

In 1987, she joined the faculty of the Albert Einstein College of Medicine, and in 2011 she moved to the Yale School of Medicine.[1]At Yale, Carrasco took the C.N.H. Long Professor of Physiology chair in 2018 and researched cancer and the liver at the Cancer and Liver Center[7] where she was also a member of the Department of Cellular and Molecular Physiology, the organizations of Genomics, Genetics and Epigenetics, and the Office of Cooperative Research.[2]

In spring of 2019, Carrasco joined the faculty of Vanderbilt University as the chair of Department of Molecular Physiology and Biophysics.[1]

Sodium/Iodide Symporter

Nancy Carrasco was the first person to clone and extensively characterize at the molecular level the sodium/iodide symporter, the key plasma membrane protein that activates the transport of iodide in the thyroid, lactating breast, and other tissues.[7][1] Much of her research has been published in different prominent medical journals including Nature Medicine.[7]

Personal life

Nancy Carrasco is married to Samuel Zyman, a composer with a degree in Medicine and a doctorate in Music Composition who is currently a faculty member at the Juilliard School.[1] Nancy and Samuel met on their first day of Medical School.[1] They have a son, Erik Zyman, who has a doctorate in linguistics and is a faculty member at the University of Chicago.[8][1]

Awards

The Pew Award is given based on biomedical research.[16] The Beckman Young Investigators Award is given to young members in the early stages of their careers in chemical and life sciences, providing them with research support.[17] Carrasco was the first person to be awarded the Maria Sibylla Merian Award, given by the Essen College of Gender Studies in 1998.[18] The Light of Life Award is given by the Light of Life Foundation to research that has impacted the understanding of Thyroid cancers.[12] The Sidney H. Ingbar Distinguished Lecturer award is given to individuals who have provided major contributions to the research on thyroid.[19]

Additionally, she serves on the editorial board of The Journal of General Physiology,[20] and has served as the President of the Society of Latin American Biophysicists.[21]

Published Works

Martín M, Modenutti CP, Peyret V, Geysels RC, Darrouzet E, Pourcher T, Masini-Repiso AM, Martí MA, Carrasco N, Nicola JP. (2019) A Carboxy-Terminal Monoleucine-Based Motif Participates in the Basolateral Targeting of the Na+/I- Symporter. Endocrinology. 160: 156–168. PMID 30496374 DOI: 10.1210/en.2018-00603[22]

Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. (2017) Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 114: E9172-E9180. PMID 29073114 DOI: 10.1073/pnas.1707797114[22]

Ferrandino G, Kaspari RR, Reyna-Neyra A, Boutagy NE, Sinusas AJ, Carrasco N. (2017) An extremely high dietary iodide supply forestalls severe hypothyroidism in Na(+)/I(-) symporter (NIS) knockout mice. Scientific Reports. 7: 5329. PMID 28706256 DOI: 10.1038/s41598-017-04326-z[22]

Ravera S, Reyna-Neyra A, Ferrandino G, Amzel LM, Carrasco N. (2017) The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications. Annual Review of Physiology. 79: 261–289. PMID 28192058 DOI: 10.1146/annurev-physiol-022516-034125[22]

Ferrandino G, Nicola JP, Sánchez YE, Echeverria I, Liu Y, Amzel LM, Carrasco N. (2016) Na+ coordination at the Na2 site of the Na+/I- symporter. Proceedings of the National Academy of Sciences of the United States of America. PMID 27562170 DOI: 10.1073/pnas.1607231113[22]

Renier C, Do J, Reyna-Neyra A, Foster D, De A, Vogel H, Jeffrey SS, Tse V, Carrasco N, Wapnir I. (2016) Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. Oncotarget. PMID 27363025 DOI: 10.18632/oncotarget.10238[22]

Ravera S, Quick M, Nicola JP, Carrasco N, Amzel LM. (2015) Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters. The Journal of General Physiology. 145: 555–63. PMID 26009546 DOI: 10.1085/jgp.201511365[22]

Nicola JP, Carrasco N, Masini-Repiso AM. (2015) Dietary I(-) absorption: expression and regulation of the Na(+)/I(-) symporter in the intestine. Vitamins and Hormones. 98: 1-31. PMID 25817864 DOI: 10.1016/bs.vh.2014.12.002[22]

Oikawa T, Wauthier E, Dinh TA, Selitsky SR, Reyna-Neyra A, Carpino G, Levine R, Cardinale V, Klimstra D, Gaudio E, Alvaro D, Carrasco N, Sethupathy P, Reid LM. (2015) Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells. Nature Communications. 6: 8070. PMID 26437858 DOI: 10.1038/ncomms9070[22]

Nicola JP, Reyna-Neyra A, Saenger P, Rodriguez-Buritica DF, Gamez Godoy JD, Muzumdar R, Amzel LM, Carrasco N. (2015) Sodium/Iodide Symporter Mutant V270E Causes Stunted Growth but No Cognitive Deficiency. The Journal of Clinical Endocrinology and Metabolism. 100: E1353-61. PMID 26204134 DOI: 10.1210/jc.2015-1824[22]

Ravera S, Quick M, Nicola JP, Carrasco N, Amzel LM. (2015) Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters. The Journal of General Physiology. 145: 555–63. PMID 26009546 DOI: 10.1085/jgp.201511365[22]

Arriagada AA, Albornoz E, Opazo MC, Becerra A, Vidal G, Fardella C, Michea L, Carrasco N, Simon F, Elorza AA, Bueno SM, Kalergis AM, Riedel CA.(2015) Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species. Endocrinology. 156: 1540–51. PMID 25594695 DOI: 10.1210/en.2014-1371[22]

References
  1. MacMillan, Leigh. "Carrasco to lead Department of Molecular Physiology and Biophysics". Vanderbilt University. Retrieved 2019-12-08.
  2. "Nancy Carrasco, MD". Yale School of Medicine. Retrieved May 13, 2019.
  3. "Nancy Carrasco". www.nasonline.org. Retrieved 2019-12-08.
  4. Dai, Ge; Levy, Orlie; Carrasco, Nancy (February 1996). "Cloning and characterization of the thyroid iodide transporter". Nature. 379 (6564): 458–460. Bibcode:1996Natur.379..458D. doi:10.1038/379458a0. ISSN 1476-4687. PMID 8559252. S2CID 4366019.
  5. "Prof. Dr. Nancy Carrasco - Maria Sibylla Merian-Preisträgerin 1998" (in German). Retrieved May 13, 2019.
  6. Carrasco, Nancy (2019-02-04). "Mentors: Ron KabackMentors: Ron Kaback". The Journal of General Physiology. 151 (2): 97–99. doi:10.1085/jgp.201912322. ISSN 0022-1295. PMC 6363408. PMID 30674562.
  7. "Dr. Nancy Carrasco named C.N.H. Long Professor". YaleNews. 2018-08-29. Retrieved 2019-12-08.
  8. MacMillan, Leigh (August 21, 2018). "Carrasco to lead Department of Molecular Physiology and Biophysics". Vanderbilt University. Retrieved May 13, 2019.
  9. "Nancy Carrasco, M.D." The Pew Charitable Trusts. Retrieved May 13, 2019.
  10. "Einstein Researcher Receives 2009 Beckman Foundation Young Investigator Award". May 13, 2009. Retrieved May 13, 2019.
  11. "Einstein Honors Dr. Nancy Carrasco With Its Third Annual Marshall S. Horwitz Faculty Prize for Research Excellence". February 27, 2009. Retrieved May 13, 2019.
  12. "LoLF Honorary Awardees". Light of Life Foundation. Retrieved May 13, 2019.
  13. "Nancy Carrasco". National Academy of Sciences. Retrieved May 13, 2019.
  14. "American Thyroid Association Announces 2016 Sidney H. Ingbar Distinguished Lectureship Award Winner". September 21, 2016. Retrieved May 13, 2019.
  15. "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. 2020-10-19. Retrieved 2020-10-21.
  16. "Program Details". pew.org. Retrieved 2019-12-08.
  17. "Beckman Young Investigator Program". Arnold and Mabel Beckman Foundation. Retrieved 2019-12-08.
  18. "Maria Sibylla Merian-Prize". www.uni-due.de. Retrieved 2019-12-08.
  19. "Sidney H. Ingbar Distinguished Lectureship Award". American Thyroid Association. Retrieved 2019-12-08.
  20. Gordon, Sharona E. (2018-02-05). "Looking in the rear-view mirror as we anticipate another 100 yearsReflecting on JGP's mission in 2018". The Journal of General Physiology. 150 (2): 169–174. doi:10.1085/jgp.201811995. ISSN 0022-1295. PMC 5806681. PMID 29367199.
  21. "Dr. Nancy Carrasco named C.N.H. Long Professor". www.myscience.org. Retrieved 2019-12-08.
  22. "Nancy Carrasco - Publications". academictree.org. Retrieved 2019-12-08.
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