Nasal embryonic LHRH factor

Nasal embryonic luteinizing hormone-releasing hormone factor is a protein that in humans is encoded by the NELF gene.[5][6][7]

NSMF
Identifiers
Aliases	NSMF, HH9, NELF, Nasal embryonic LHRH factor, NMDA receptor synaptonuclear signaling and neuronal migration factor
External IDs	OMIM: 608137 MGI: 1861755 HomoloGene: 10648 GeneCards: NSMF
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,447,573 bp[1] End 137,459,334 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,054,355 bp[2] End 25,062,881 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium-dependent protein binding Cellular component • cytoplasm • apical dendrite • nuclear euchromatin • perikaryon • postsynaptic membrane • cell projection • not the membrane • nuclear envelope • membrane • GO:0097483, GO:0097481 postsynaptic density • nuclear matrix • cortical cytoskeleton • cell membrane • synapse • nucleoplasm • cell junction • dendrite • cell cortex • neuron projection • cytoskeleton • cell nucleus Biological process • positive regulation of protein dephosphorylation • regulation of neuron apoptotic process • positive regulation of neuron migration • regulation of dendrite morphogenesis • cellular response to amino acid stimulus • cellular response to gonadotropin stimulus • cellular response to electrical stimulus • regulation of neuron migration • regulation of neuronal synaptic plasticity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26012	56876
Ensembl	ENSG00000165802	ENSMUSG00000006476
UniProt	Q6X4W1	Q99NF2
RefSeq (mRNA)	NM_001130969 NM_001130970 NM_001130971 NM_001178064 NM_015537	NM_001039386 NM_001039387 NM_001177654 NM_001177655 NM_020276
RefSeq (protein)	NP_001124441 NP_001124442 NP_001124443 NP_001171535 NP_056352	NP_001034475 NP_001034476 NP_001171125 NP_001171126 NP_064672
Location (UCSC)	Chr 9: 137.45 – 137.46 Mb	Chr 2: 25.05 – 25.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000165802 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006476 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Kramer PR, Wray S (Jul 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes & Development. 14 (14): 1824–34. doi:10.1101/gad.14.14.1824 (inactive 2021-01-13). PMC 316793. PMID 10898796.CS1 maint: DOI inactive as of January 2021 (link)
7. "Entrez Gene: NELF nasal embryonic LHRH factor".

Further reading

• Miura K, Acierno JS, Seminara SB (2004). "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)". Journal of Human Genetics. 49 (5): 265–8. doi:10.1007/s10038-004-0137-4. PMID 15362570.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.