New methylene blue

New methylene blue (also NMB) is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.[1]

New methylene blue

Identifiers
CAS Number	1934-16-3
3D model (JSmol)	Interactive image
ChemSpider	16736255
ECHA InfoCard	100.026.833
PubChem CID	73518
UNII	5GCZ112BCN
InChI InChI=1S/C18H22N3S.ClH/c1-5-19-13-9-17-15(7-11(13)3)21-16-8-12(4)14(20-6-2)10-18(16)22-17;/h7-10,19-20H,5-6H2,1-4H3;1H/q+1;/p-1 Key: NZYCYASKVWSANA-UHFFFAOYSA-M InChI=1/C18H22N3S.ClH/c1-5-19-13-9-17-15(7-11(13)3)21-16-8-12(4)14(20-6-2)10-18(16)22-17;/h7-10,19-20H,5-6H2,1-4H3;1H/q+1;/p-1 Key: NZYCYASKVWSANA-REWHXWOFAR
SMILES [Cl-].Cc1cc2nc3cc(C)c(cc3[s+]c2cc1NCC)NCC
Properties
Chemical formula	C18H22N3S:SCl ZnCl2
Molar mass	484.22 g/mol
Melting point	239 °C (462 °F; 512 K)
Boiling point	Decomposes
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Applications

NMB is a staining agent used in diagnostic cytopathology and histopathology, typically for staining immature red blood cells. It is a supravital stain.[2] It is closely related to methylene blue, an older stain in wide use.

Safety

New methylene blue is toxic. Skin contact or inhalation should be avoided.

See also

• Methylene blue

References

1. Vennerstrom, Jonathan L.; Makler, Michael T.; Angerhofer, Cidy K.; Williams, Jean A. "Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazine" Antimicrobial Agents and Chemotherapy (1995), 39(12), 2671–7. doi:10.1128/AAC.39.12.2671.
2. "Reticulocyte Count" (PDF). Prentice-Hall.