O-demethylpuromycin O-methyltransferase
In enzymology, an O-demethylpuromycin O-methyltransferase (EC 2.1.1.38) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + O-demethylpuromycin S-adenosyl-L-homocysteine + puromycin
| O-demethylpuromycin O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.38 | ||||||||
| CAS number | 37257-04-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and O-demethylpuromycin, whereas its two products are S-adenosylhomocysteine and puromycin.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase. This enzyme is also called O-demethylpuromycin methyltransferase. This enzyme participates in puromycin biosynthesis.
References
- Rao MM, Rebello PF, Pogell BM (1969). "Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin". J. Biol. Chem. 244 (1): 112–8. PMID 5773275.
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