ODF2

Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.[5][6][7]

ODF2
Identifiers
Aliases	ODF2, CT134, ODF2/1, ODF2/2, ODF84, outer dense fiber of sperm tails 2
External IDs	OMIM: 602015 MGI: 1098824 HomoloGene: 1907 GeneCards: ODF2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,455,186 bp[1] End 128,501,292 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 20.79 cM Start 29,889,221 bp[2] End 29,931,746 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • Rab GTPase binding • GO:0001948 protein binding Cellular component • cytoplasm • ciliary basal body • cytosol • cell projection • spindle pole • outer dense fiber • ciliary transition fiber • microtubule organizing center • centriole • microtubules • cytoskeleton • cell nucleus • centrosome • cilium • motile cilium • sperm flagellum • centriolar subdistal appendage Biological process • cell differentiation • multicellular organism development • G2/M transition of mitotic cell cycle • spermatogenesis • spermatid development • regulation of cilium assembly • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle • protein localization • centriole-centriole cohesion • cilium organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4957	18286
Ensembl	ENSG00000136811	ENSMUSG00000026790
UniProt	Q5BJF6	A3KGV1
RefSeq (mRNA)	NM_001242352 NM_001242353 NM_001242354 NM_002540 NM_153432 NM_153433 NM_153435 NM_153436 NM_153437 NM_153439 NM_153440 NM_001351577 NM_001351578 NM_001351579 NM_001351580 NM_001351581 NM_001351582 NM_001351583 NM_001351584 NM_001351585 NM_001351586 NM_001351587 NM_001351588	NM_001113213 NM_001113214 NM_001177659 NM_001177661 NM_013615 NM_001355136 NM_001355137 NM_001355138 NM_001369060 NM_001374179 NM_001374180 NM_001374181 NM_001374182
RefSeq (protein)	NP_001229281 NP_001229282 NP_001229283 NP_002531 NP_702910 NP_702911 NP_702913 NP_702914 NP_702915 NP_702917 NP_702918 NP_001338506 NP_001338507 NP_001338508 NP_001338509 NP_001338510 NP_001338511 NP_001338512 NP_001338513 NP_001338514 NP_001338515 NP_001338516 NP_001338517	NP_001106684 NP_001106685 NP_001171130 NP_001171132 NP_038643 NP_001342065 NP_001342066 NP_001342067 NP_001355989 NP_001361108 NP_001361109 NP_001361110 NP_001361111
Location (UCSC)	Chr 9: 128.46 – 128.5 Mb	Chr 2: 29.89 – 29.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000136811 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026790 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shao X, Tarnasky HA, Schalles U, Oko R, van der Hoorn FA (Apr 1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J Biol Chem. 272 (10): 6105–13. doi:10.1074/jbc.272.10.6105. PMID 9045620.
6. Shao X, Murthy S, Demetrick DJ, van der Hoorn FA (Mar 1999). "Human outer dense fiber gene, ODF2, localizes to chromosome 9q34". Cytogenet Cell Genet. 83 (3–4): 221–3. doi:10.1159/000015183. hdl:1807.1/828. PMID 10072582. S2CID 1214379.
7. "Entrez Gene: ODF2 outer dense fiber of sperm tails 2".

Further reading

• Kierszenbaum AL (2002). "Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells". Mol. Reprod. Dev. 61 (1): 1–2. doi:10.1002/mrd.1124. PMID 11774369. S2CID 28475473.
• Hoyer-Fender S, Petersen C, Brohmann H, et al. (1999). "Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail". Mol. Reprod. Dev. 51 (2): 167–75. doi:10.1002/(SICI)1098-2795(199810)51:2<167::AID-MRD6>3.0.CO;2-O. PMID 9740324.
• Petersen C, Füzesi L, Hoyer-Fender S (1999). "Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa". Mol. Hum. Reprod. 5 (7): 627–35. doi:10.1093/molehr/5.7.627. PMID 10381817.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Soung NK, Kang YH, Kim K, et al. (2007). "Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes". Mol. Cell. Biol. 26 (22): 8316–35. doi:10.1128/MCB.00671-06. PMC 1636773. PMID 16966375.