ORM1

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.[3]

ORM1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3KQ0
Identifiers
Aliases	ORM1, AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDs	OMIM: 138600 HomoloGene: 128040 GeneCards: ORM1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 114,323,056 bp[1] End 114,326,475 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • blood microparticle • extracellular exosome • platelet alpha granule lumen • extracellular • specific granule lumen • tertiary granule lumen • extracellular matrix • extracellular region • collagen-containing extracellular matrix Biological process • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production • regulation of immune system process • inflammatory response • acute-phase response • platelet degranulation • neutrophil degranulation • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5004	n/a
Ensembl	ENSG00000229314	n/a
UniProt	P02763	n/a
RefSeq (mRNA)	NM_000607	n/a
RefSeq (protein)	NP_000598	n/a
Location (UCSC)	Chr 9: 114.32 – 114.33 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.[3]

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1.[4]

See also

• Orosomucoid

References

1. GRCh38: Ensembl release 89: ENSG00000229314 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: ORM1 orosomucoid 1".
4. Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. United States. 276 (38): 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606.

Further reading

• Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein". Biochem. J. 283 (1): 105–12. doi:10.1042/bj2830105. PMC 1131000. PMID 1567356.
• Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes". Nucleic Acids Res. 13 (11): 3941–52. doi:10.1093/nar/13.11.3941. PMC 341288. PMID 2409529.
• Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate". Prostate. 15 (3): 251–8. doi:10.1002/pros.2990150305. PMID 2479939. S2CID 84445745.
• Zuffardi O, Caiulo A, Maraschio P, et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. doi:10.1007/bf00288264. PMID 2541064. S2CID 42021177.
• Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein". EMBO J. 6 (8): 2289–96. doi:10.1002/j.1460-2075.1987.tb02503.x. PMC 553631. PMID 2822385.
• Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene". Gene. 66 (1): 97–106. doi:10.1016/0378-1119(88)90228-4. PMID 2970990.
• Dente L, Rüther U, Tripodi M, et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice". Genes Dev. 2 (2): 259–66. doi:10.1101/gad.2.2.259. PMID 3360326.
• Rocchi M, Roncuzzi L, Santamaria R, et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9". Hum. Genet. 74 (1): 30–3. doi:10.1007/BF00278781. PMID 3463531. S2CID 34725840.
• Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA". Gene. 44 (1): 127–31. doi:10.1016/0378-1119(86)90051-X. PMID 3770479.
• Krauss E, Polnaszek CF, Scheeler DA, et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID 3795040.
• Ikenaka T, Ishiguro M, Emura J, et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment". Biochemistry. 11 (20): 3817–29. doi:10.1021/bi00770a022. PMID 4561179.
• Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein". Biochemistry. 13 (13): 2694–7. doi:10.1021/bi00710a006. PMID 4603214.
• Schmid K, Kaufmann H, Isemura S, et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins". Biochemistry. 12 (14): 2711–24. doi:10.1021/bi00738a026. PMID 4711474.
• Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE". Calcif. Tissue Int. 34 (3): 229–31. doi:10.1007/BF02411242. PMID 6809283. S2CID 13305518.
• Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans". Glycoconj. J. 12 (1): 7–16. doi:10.1007/BF00731863. PMID 7795416. S2CID 23508679.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Nakamura T, Board PG, Matsushita K, et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis" (PDF). Inflammation. 17 (1): 33–45. doi:10.1007/BF00916390. hdl:2027.42/44509. PMID 8432561. S2CID 6012698.
• Yuasa I, Umetsu K, Vogt U, et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S". Hum. Genet. 99 (3): 393–8. doi:10.1007/s004390050378. PMID 9050929. S2CID 21298011.
• Morin D, Simon N, Deprés-Brummer P, et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum". Pharmacology. 54 (5): 271–5. doi:10.1159/000139495. PMID 9380773.
• Nakamura H, Yuasa I, Umetsu K, et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID 11027547.