OTUD4

OTU domain-containing protein 4 is a protein that in humans is encoded by the OTUD4 gene.[5][6][7]

OTUD4
Identifiers
Aliases	OTUD4, DUBA6, HIN1, HSHIN1, OTU deubiquitinase 4
External IDs	OMIM: 611744 MGI: 1098801 HomoloGene: 35370 GeneCards: OTUD4
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 145,110,838 bp[1] End 145,180,589 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C1|8 37.74 cM Start 79,639,618 bp[2] End 79,677,724 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • thiol-dependent ubiquitin-specific protease activity • peptidase activity • cysteine-type peptidase activity • GO:0001948 protein binding • hydrolase activity • RNA binding • GO:0032947 molecular adaptor activity • Lys63-specific deubiquitinase activity Cellular component • cellular component • cell nucleus • cytoplasm Biological process • protein K48-linked deubiquitination • proteolysis • immune system process • negative regulation of toll-like receptor signaling pathway • innate immune system • protein K63-linked deubiquitination • positive regulation of DNA demethylation • regulation of protein K48-linked deubiquitination • negative regulation of interleukin-1-mediated signaling pathway • protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54726	73945
Ensembl	ENSG00000164164	ENSMUSG00000036990
UniProt	Q01804	B2RRE7
RefSeq (mRNA)	NM_001102653 NM_017493 NM_199324 NM_001366057 NM_001366058	NM_001081164 NM_001256033
RefSeq (protein)	NP_001096123 NP_059963 NP_001352986 NP_001352987	NP_001074633 NP_001242962
Location (UCSC)	Chr 4: 145.11 – 145.18 Mb	Chr 8: 79.64 – 79.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164164 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036990 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Raineri I, Senn HP (Feb 1993). "HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts". Nucleic Acids Res. 20 (23): 6261–6. doi:10.1093/nar/20.23.6261. PMC 334514. PMID 1475186.
6. Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K (May 2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors". Cancer Res. 63 (9): 2024–7. PMID 12727813.
7. "Entrez Gene: OTUD4 OTU domain containing 4".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.