Ovomucoid

Ovomucoid
Identifiers
Organism	Gallus gallus
Symbol	?
UniProt	P01005
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

Ovomucoid
	The third Kazal domain of the turkey ovomucoid protein (orange) bound to subtilisin Carlsberg, a serine protease.[1]
Identifiers
Organism	Meleagris gallopavo
Symbol	?
UniProt	P68390
Search for
Structures	Swiss-model
Domains	InterPro

Ovomucoid is a protein found in egg whites. It is a trypsin inhibitor with three protein domains of the Kazal domain family.[2][3] The homologs from chickens (Gallus gallus) and especially turkeys (Meleagris gallopavo) are best characterized. It is not related to the similarly-named ovomucin, another egg white protein.

Chicken ovomucoid, also known as Gal d 1, is a known allergen. It is the protein most often causing egg allergy. At least four IgE epitopes have been identified.[4] Three other egg white proteins are also identified as allergenic: ovalbumin (Gal d 2), ovotransferrin (Gal d 3) and lysozyme (Gal d 4).[5]

References

Horn JR, Ramaswamy S, Murphy KP (August 2003). "Structure and energetics of protein-protein interactions: the role of conformational heterogeneity in OMTKY3 binding to serine proteases". Journal of Molecular Biology. 331 (2): 497–508. doi:10.1016/S0022-2836(03)00783-6. PMID 12888355.
Lineweaver H, Murray CW (December 1947). "Identification of the trypsin inhibitor of egg white with ovomucoid". The Journal of Biological Chemistry. 171 (2): 565–81. PMID 20272096.
Rimphanitchayakit V, Tassanakajon A (April 2010). "Structure and function of invertebrate Kazal-type serine proteinase inhibitors". Developmental and Comparative Immunology. 34 (4): 377–86. doi:10.1016/j.dci.2009.12.004. PMID 19995574.
Järvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA (July 2007). "Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy". Allergy. 62 (7): 758–65. doi:10.1111/j.1398-9995.2007.01332.x. PMID 17573723.
Caubet JC, Wang J (2011). "Current understanding of egg allergy". Pediatr. Clin. North Am. 58 (2): 427–43, xi. doi:10.1016/j.pcl.2011.02.014. PMC 3069662. PMID 21453811.

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[horn_2003-1] Horn JR, Ramaswamy S, Murphy KP (August 2003). "Structure and energetics of protein-protein interactions: the role of conformational heterogeneity in OMTKY3 binding to serine proteases". Journal of Molecular Biology. 331 (2): 497–508. doi:10.1016/S0022-2836(03)00783-6. PMID 12888355.

[lineweaver_1947-2] Lineweaver H, Murray CW (December 1947). "Identification of the trypsin inhibitor of egg white with ovomucoid". The Journal of Biological Chemistry. 171 (2): 565–81. PMID 20272096.

[rimphan_2010-3] Rimphanitchayakit V, Tassanakajon A (April 2010). "Structure and function of invertebrate Kazal-type serine proteinase inhibitors". Developmental and Comparative Immunology. 34 (4): 377–86. doi:10.1016/j.dci.2009.12.004. PMID 19995574.

[jarvinen-4] Järvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA (July 2007). "Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy". Allergy. 62 (7): 758–65. doi:10.1111/j.1398-9995.2007.01332.x. PMID 17573723.

[Caubet-5] Caubet JC, Wang J (2011). "Current understanding of egg allergy". Pediatr. Clin. North Am. 58 (2): 427–43, xi. doi:10.1016/j.pcl.2011.02.014. PMC 3069662. PMID 21453811.