PARD6B

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.[5][6]

PARD6B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NF3
Identifiers
Aliases	PARD6B, PAR6B, par-6 family cell polarity regulator beta
External IDs	OMIM: 608975 MGI: 2135605 HomoloGene: 23302 GeneCards: PARD6B
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 50,731,580 bp[1] End 50,756,795 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 168,081,004 bp[2] End 168,101,203 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein kinase C binding • Rho GTPase binding Cellular component • membrane • bicellular tight junction • cell membrane • apical part of cell • cell junction • cell cortex • extracellular exosome • cell nucleus • cytoplasm • cytosol • apical plasma membrane • macromolecular complex Biological process • regulation of cell migration • axonogenesis • cell division • bicellular tight junction assembly • cell cycle • cell-cell junction assembly • establishment or maintenance of cell polarity • centrosome cycle • regulation of cellular localization • macromolecular complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84612	58220
Ensembl	ENSG00000124171	ENSMUSG00000044641
UniProt	Q9BYG5	Q9JK83
RefSeq (mRNA)	NM_032521	NM_021409
RefSeq (protein)	NP_115910	NP_067384
Location (UCSC)	Chr 20: 50.73 – 50.76 Mb	Chr 2: 168.08 – 168.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.[6]

Interactions

PARD6B has been shown to interact with:

• CDC42,[5][7][8]
• Protein kinase Mζ,[5]
• RAC1,[5] and
• RHOQ.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000124171 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044641 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
6. "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)".
7. Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
8. Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

Further reading

• Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
• Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
• Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
• Hurd TW, Gao L, Roh MH, Macara IG, Margolis B (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177. S2CID 25212419.
• Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. doi:10.1016/S0960-9822(03)00244-6. PMID 12725730. S2CID 18570360.
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
• Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. doi:10.1073/pnas.0409578102. PMC 547886. PMID 15677324.