PCDH1

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.[5][6]

PCDH1
Identifiers
Aliases	PCDH1, PC42, PCDH42, protocadherin 1
External IDs	OMIM: 603626 MGI: 104692 HomoloGene: 12613 GeneCards: PCDH1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,853,111 bp[1] End 141,879,246 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 20.08 cM Start 38,185,914 bp[2] End 38,212,053 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • intercellular junction • cell nucleus • nucleolus • cell junction • intracellular membrane-bounded organelle Biological process • cell-cell signaling • cell adhesion • nervous system development • homophilic cell adhesion via plasma membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5097	75599
Ensembl	ENSG00000156453	ENSMUSG00000051375
UniProt	Q08174	n/a
RefSeq (mRNA)	NM_001278613 NM_001278615 NM_002587 NM_032420	NM_029357
RefSeq (protein)	NP_001265542 NP_001265544 NP_002578 NP_115796	n/a
Location (UCSC)	Chr 5: 141.85 – 141.88 Mb	Chr 18: 38.19 – 38.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracellular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000156453 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051375 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system". EMBO J. 12 (6): 2249–56. doi:10.1002/j.1460-2075.1993.tb05878.x. PMC 413453. PMID 8508762.
6. "Entrez Gene: PCDH1 protocadherin 1".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169 (inactive 2021-01-13). PMID 10817752.CS1 maint: DOI inactive as of January 2021 (link)
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Del Mastro RG, Wang L, Simmons AD, et al. (1997). "Human chromosome-specific cDNA libraries: new tools for gene identification and genome annotation". Genome Res. 5 (2): 185–94. doi:10.1101/gr.5.2.185. PMID 9132272.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. S2CID 18659460.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.