PELI2

Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene.[5][6][7]

PELI2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EGA, 3EGB
Identifiers
Aliases	PELI2, pellino E3 ubiquitin protein ligase family member 2
External IDs	OMIM: 614798 MGI: 1891445 HomoloGene: 41431 GeneCards: PELI2
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 56,117,814 bp[1] End 56,301,524 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C1|14 24.6 cM Start 48,120,823 bp[2] End 48,281,575 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • ubiquitin-ubiquitin ligase activity • protein serine/threonine kinase activity • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cellular component • cytosol Biological process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of protein phosphorylation • protein ubiquitination • positive regulation of MAPK cascade • protein polyubiquitination • protein phosphorylation • immune response • Toll signaling pathway • interleukin-1-mediated signaling pathway • regulation of Toll signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57161	93834
Ensembl	ENSG00000139946	ENSMUSG00000021846
UniProt	Q9HAT8	Q8BST6
RefSeq (mRNA)	NM_021255	NM_033602
RefSeq (protein)	NP_067078	NP_291080
Location (UCSC)	Chr 14: 56.12 – 56.3 Mb	Chr 14: 48.12 – 48.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000139946 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021846 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–4. doi:10.1159/000056895. PMID 11306823.
6. Strelow A, Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405.
7. "Entrez Gene: PELI2 pellino homolog 2 (Drosophila)".

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu Y, Dong W, Chen L, et al. (2004). "BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2". J. Biol. Chem. 279 (36): 37436–44. doi:10.1074/jbc.M400241200. PMID 15213237.
• Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2–3): 199–202. doi:10.1016/S0014-5793(03)00533-7. PMID 12804775.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu KY, Kwon HJ, Norman DA, et al. (2002). "Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling". J. Immunol. 169 (8): 4075–8. doi:10.4049/jimmunol.169.8.4075. PMID 12370331.