PHC3

Polyhomeotic-like protein 3 is a protein that in humans is encoded by the PHC3 gene.[5][6][7]

PHC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PZN, 4PZO
Identifiers
Aliases	PHC3, EDR3, HPH3, polyhomeotic homolog 3
External IDs	MGI: 2181434 HomoloGene: 69390 GeneCards: PHC3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 170,086,732 bp[1] End 170,181,749 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 30,899,371 bp[2] End 30,969,415 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • zinc ion binding • GO:0001948 protein binding • metal ion binding Cellular component • PcG protein complex • PRC1 complex • cell nucleus • nucleoplasm Biological process • multicellular organism development • negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80012	241915
Ensembl	ENSG00000173889	ENSMUSG00000037652
UniProt	Q8NDX5	Q8CHP6
RefSeq (mRNA)	NM_001308116 NM_024947	NM_001165954 NM_001165955 NM_001165956 NM_153421
RefSeq (protein)	NP_001295045 NP_079223	NP_001159426 NP_001159427 NP_001159428 NP_700470
Location (UCSC)	Chr 3: 170.09 – 170.18 Mb	Chr 3: 30.9 – 30.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000173889 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037652 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Aug 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol Cell Biol. 22 (17): 6070–6078. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
6. Tonkin E, Hagan DM, Li W, Strachan T (Oct 2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Hum Genet. 111 (4–5): 435–442. doi:10.1007/s00439-002-0814-3. PMID 12384788. S2CID 22192470.
7. "Entrez Gene: PHC3 polyhomeotic homolog 3 (Drosophila)".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–5396. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Deshpande AM, Akunowicz JD, Reveles XT, et al. (2007). "PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors". Oncogene. 26 (12): 1714–1722. doi:10.1038/sj.onc.1209988. PMC 2691996. PMID 17001316.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.