PHLPP (gene)

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.[5]

PHLPP1
Identifiers
Aliases	PHLPP1, PHLPP, PLEKHE1, SCOP, PPM3A, PH domain and leucine rich repeat protein phosphatase 1
External IDs	OMIM: 609396 MGI: 2138327 HomoloGene: 11015 GeneCards: PHLPP1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.33 Start 62,715,541 bp[1] End 62,980,433 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.1 Start 106,171,752 bp[2] End 106,394,250 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphoprotein phosphatase activity • metal ion binding • GO:0001948 protein binding • catalytic activity • hydrolase activity • protein serine/threonine phosphatase activity Cellular component • cytosol • membrane • cell nucleus • cytoplasm • cell membrane • not the membrane • photoreceptor inner segment • photoreceptor outer segment membrane Biological process • regulation of apoptotic process • regulation of MAPK cascade • protein dephosphorylation • entrainment of circadian clock • regulation of JNK cascade • regulation of T cell anergy • regulation of p38MAPK cascade • apoptotic process • regulation of protein kinase C signaling • negative regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23239	98432
Ensembl	ENSG00000081913	ENSMUSG00000044340
UniProt	O60346	Q8CHE4
RefSeq (mRNA)	NM_194449	NM_133821
RefSeq (protein)	NP_919431	NP_598582
Location (UCSC)	Chr 18: 62.72 – 62.98 Mb	Chr 1: 106.17 – 106.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• PHLPP

References

1. GRCh38: Ensembl release 89: ENSG00000081913 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044340 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Shimizu K, Okada M, Takano A, Nagai K (2000). "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus". FEBS Lett. 458 (3): 363–9. doi:10.1016/S0014-5793(99)01190-4. PMID 10570941. S2CID 38044717.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gao T, Furnari F, Newton AC (2005). "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth". Mol. Cell. 18 (1): 13–24. doi:10.1016/j.molcel.2005.03.008. PMID 15808505.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. doi:10.1038/nature03983. PMID 16177791.
• Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms". Mol. Cell. 25 (6): 917–31. doi:10.1016/j.molcel.2007.02.017. PMID 17386267.