PIGW

Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene. [5]

PIGW
Identifiers
Aliases	PIGW, Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W
External IDs	OMIM: 610275 MGI: 1917575 HomoloGene: 6243 GeneCards: PIGW
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 36,534,987 bp[1] End 36,539,310 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 84,876,315 bp[2] End 84,880,285 bp[2]
Gene ontology Molecular function • transferase activity, transferring acyl groups • transferase activity • O-acyltransferase activity • glucosaminyl-phosphotidylinositol O-acyltransferase activity Cellular component • membrane • endoplasmic reticulum membrane • integral component of membrane • endoplasmic reticulum Biological process • GPI anchor biosynthetic process • GPI anchor metabolic process • protein localization to plasma membrane • preassembly of GPI anchor in ER membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284098	70325
Ensembl	ENSG00000275600 ENSG00000277161	ENSMUSG00000045140
UniProt	Q7Z7B1	Q8C398
RefSeq (mRNA)	NM_178517 NM_001346754 NM_001346755	NM_001077636 NM_027388 NM_001363112
RefSeq (protein)	NP_001333683 NP_001333684 NP_848612	NP_001071104 NP_081664 NP_001350041
Location (UCSC)	Chr 17: 36.53 – 36.54 Mb	Chr 11: 84.88 – 84.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).

References

1. ENSG00000277161 GRCh38: Ensembl release 89: ENSG00000275600, ENSG00000277161 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045140 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Phosphatidylinositol glycan anchor biosynthesis class W". Retrieved 2016-10-29.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.