PIP4K2B

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.[5][6][7][8]

PIP4K2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BO1, 3WZZ, 3X01, 3X02, 3X03, 3X04, 3X05, 3X06, 3X07, 3X08, 3X09, 3X0A, 3X0B, 3X0C
Identifiers
Aliases	PIP4K2B, PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
External IDs	OMIM: 603261 MGI: 1934234 HomoloGene: 2634 GeneCards: PIP4K2B
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,765,689 bp[1] End 38,800,126 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.07 cM Start 97,715,157 bp[2] End 97,744,704 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • 1-phosphatidylinositol-4-phosphate 5-kinase activity • kinase activity • phosphatidylinositol phosphate kinase activity • GO:0001948 protein binding • ATP binding • 1-phosphatidylinositol-3-phosphate 4-kinase activity • 1-phosphatidylinositol-5-phosphate 4-kinase activity • protein homodimerization activity Cellular component • cytoplasm • cytosol • endoplasmic reticulum membrane • membrane • cell membrane • autophagosome • endoplasmic reticulum • cell nucleus • nucleoplasm Biological process • phosphatidylinositol metabolic process • positive regulation of autophagosome assembly • phosphorylation • cell surface receptor signaling pathway • regulation of autophagy • phosphatidylinositol biosynthetic process • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8396	108083
Ensembl	ENSG00000277292 ENSG00000276293	ENSMUSG00000018547
UniProt	P78356	Q80XI4
RefSeq (mRNA)	NM_003559 NM_138687	NM_054051
RefSeq (protein)	NP_003550	NP_473392
Location (UCSC)	Chr 17: 38.77 – 38.8 Mb	Chr 11: 97.72 – 97.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.[8]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A.[5] In addition, PIP4K2B has been shown to interact with PIP4K2A and may modulate the cellular localisation of PIP4K2A.[9]

Structure

The structure of PIP4K2B has been determined through X-ray crystallography.[10]

References

1. ENSG00000276293 GRCh38: Ensembl release 89: ENSG00000277292, ENSG00000276293 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018547 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi:10.1074/jbc.272.9.5861. PMID 9038203.
6. Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi:10.1038/sj.onc.1207251. PMID 14691457.
7. Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. Bibcode:1997Natur.390..192R. doi:10.1038/36621. PMID 9367159. S2CID 4403301.
8. "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".
9. Bultsma, Yvette; Keune, Willem-Jan; Divecha, Nullin (2010-09-01). "PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα". Biochemical Journal. 430 (2): 223–235. doi:10.1042/bj20100341. ISSN 0264-6021. PMID 20583997.
10. Rao, Vibha D; Misra, Saurav; Boronenkov, Igor V; Anderson, Richard A; Hurley, James H (1998). "Structure of Type IIβ Phosphatidylinositol Phosphate Kinase". Cell. 94 (6): 829–839. doi:10.1016/s0092-8674(00)81741-9. PMID 9753329. S2CID 18221569.

Further reading

• Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1". Immunity. 19 (5): 637–40. doi:10.1016/S1074-7613(03)00303-0. PMID 14614850.
• Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/BST0320326. PMID 15046600.
• Rao VD, Misra S, Boronenkov IV, et al. (1998). "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation". Cell. 94 (6): 829–39. doi:10.1016/S0092-8674(00)81741-9. PMID 9753329. S2CID 18221569.
• Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1999). "Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors". Mol. Biol. Cell. 9 (12): 3547–60. doi:10.1091/mbc.9.12.3547. PMC 25675. PMID 9843587.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Richardson JP, Wang M, Clarke JH, et al. (2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation". Cell. Signal. 19 (6): 1309–14. doi:10.1016/j.cellsig.2007.01.010. PMC 1868964. PMID 17303380.