PJA1

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.[5][6]

PJA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L0B
Identifiers
Aliases	PJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1
External IDs	OMIM: 300420 MGI: 1101765 HomoloGene: 129620 GeneCards: PJA1
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 69,160,851 bp[1] End 69,165,793 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X C3|X 43.38 cM Start 99,465,734 bp[2] End 99,471,273 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • transferase activity Cellular component • cytoplasm Biological process • protein catabolic process • protein ubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64219	18744
Ensembl	ENSG00000181191	ENSMUSG00000034403
UniProt	Q8NG27	O55176
RefSeq (mRNA)	NM_001032396 NM_022368 NM_145119 NM_001382775 NM_001382776	NM_001083110 NM_001290555 NM_001290556 NM_008853
RefSeq (protein)	NP_001027568 NP_071763 NP_660095 NP_001369704 NP_001369705	NP_001076579 NP_001277484 NP_001277485 NP_032879
Location (UCSC)	Chr X: 69.16 – 69.17 Mb	Chr X: 99.47 – 99.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PJA1 has been shown to interact with UBE2D2[5] and MAGED1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000181191 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034403 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
6. "Entrez Gene: PJA1 praja 1".
7. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

Further reading

• Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, et al. (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
• Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (March 2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". The Journal of Biological Chemistry. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
• Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.