PKIG

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.[5][6]

PKIG
Identifiers
Aliases	PKIG, PKI-gamma, protein kinase (cAMP-dependent, catalytic) inhibitor gamma, cAMP-dependent protein kinase inhibitor gamma
External IDs	OMIM: 604932 MGI: 1343086 HomoloGene: 5133 GeneCards: PKIG
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 44,531,785 bp[1] End 44,624,247 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 84.4 cM Start 163,658,386 bp[2] End 163,726,158 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase inhibitor activity • cAMP-dependent protein kinase inhibitor activity Cellular component • cytoplasm • cell nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • negative regulation of cAMP-dependent protein kinase activity • signal transduction • negative regulation of protein kinase activity • negative regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11142	18769
Ensembl	ENSG00000168734	ENSMUSG00000035268
UniProt	Q9Y2B9	O70139
RefSeq (mRNA)	NM_181805 NM_001281444 NM_001281445 NM_007066 NM_181804	NM_001039390 NM_001039391 NM_001164053 NM_001164055 NM_001277096 NM_011106
RefSeq (protein)	NP_001268373 NP_001268374 NP_008997 NP_861520 NP_861521	NP_001034479 NP_001034480 NP_001157525 NP_001157527 NP_001264025 NP_035236
Location (UCSC)	Chr 20: 44.53 – 44.62 Mb	Chr 2: 163.66 – 163.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000168734 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035268 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
6. "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

Further reading

• Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase". J. Biol. Chem. 272 (29): 18169–78. doi:10.1074/jbc.272.29.18169. PMID 9218452.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor". Am. J. Physiol., Cell Physiol. 282 (1): C59–66. doi:10.1152/ajpcell.00256.2001. PMID 11742798.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation". Int. J. Biochem. Cell Biol. 38 (12): 2064–73. doi:10.1016/j.biocel.2006.05.015. PMID 16870489.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.