PLAGL2

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.[5][6][7]

PLAGL2
Identifiers
Aliases	PLAGL2, ZNF900, PLAG1 like zinc finger 2
External IDs	OMIM: 604866 MGI: 1933165 HomoloGene: 1994 GeneCards: PLAGL2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 32,192,504 bp[1] End 32,207,743 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 153,227,759 bp[2] End 153,241,426 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • DNA binding • nucleic acid binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • regulation of transcription, DNA-templated • chylomicron assembly • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • lipid metabolism • positive regulation of intrinsic apoptotic signaling pathway • post-embryonic development • transcription from RNA polymerase II promoter • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5326	54711
Ensembl	ENSG00000126003	ENSMUSG00000051413
UniProt	Q9UPG8	Q925T4
RefSeq (mRNA)	NM_002657	NM_018807
RefSeq (protein)	NP_002648	NP_061277
Location (UCSC)	Chr 20: 32.19 – 32.21 Mb	Chr 2: 153.23 – 153.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA.[7]

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000126003 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051413 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (Mar 2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652.
6. Zheng G, Ning J, Yang YC (Oct 2007). "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53". Biochem Biophys Res Commun. 364 (2): 344–50. doi:10.1016/j.bbrc.2007.10.003. PMC 2708094. PMID 17950244.
7. "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2".
8. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA (May 2010). "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma". Cancer Cell. 17 (5): 497–509. doi:10.1016/j.ccr.2010.03.020. PMC 2900858. PMID 20478531.

Further reading

• Guo Y, Yang MC, Weissler JC, Yang YS (2007). "PLAGL2 Translocation and SP-C Promoter Activity – A Cellular Response of Lung Cells to Hypoxia". Biochem. Biophys. Res. Commun. 360 (3): 659–65. doi:10.1016/j.bbrc.2007.06.106. PMC 2084061. PMID 17618602.
• Ammons MC, Siemsen DW, Nelson-Overton LK, et al. (2007). "Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity". J. Biol. Chem. 282 (24): 17941–52. doi:10.1074/jbc.M610618200. PMID 17462995.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang MC, Weissler JC, Terada LS, et al. (2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. Respir. Cell Mol. Biol. 32 (1): 35–43. CiteSeerX 10.1.1.325.6715. doi:10.1165/rcmb.2003-0422OC. PMID 15361364.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Furukawa T, Adachi Y, Fujisawa J, et al. (2001). "Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines". Oncogene. 20 (34): 4718–27. doi:10.1038/sj.onc.1204647. PMID 11498794.
• Kas K, Voz ML, Hensen K, et al. (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.