PLP2

Proteolipid protein 2 is a protein that in humans is encoded by the PLP2 gene.[5][6][7]

PLP2
Identifiers
Aliases	PLP2, A4, A4LSB, proteolipid protein 2 (colonic epithelium-enriched), proteolipid protein 2
External IDs	OMIM: 300112 MGI: 1298382 HomoloGene: 2003 GeneCards: PLP2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 49,171,898 bp[1] End 49,175,235 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.1|X 3.45 cM Start 7,667,941 bp[2] End 7,671,390 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ion transmembrane transporter activity • GO:0001948 protein binding • chemokine binding Cellular component • membrane • endoplasmic reticulum membrane • cell membrane • endoplasmic reticulum • integral component of membrane Biological process • cytokine-mediated signaling pathway • chemotaxis • ion transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5355	18824
Ensembl	ENSG00000102007	ENSMUSG00000031146
UniProt	Q04941	Q9R1Q7
RefSeq (mRNA)	NM_002668	NM_019755
RefSeq (protein)	NP_002659 NP_002659.1	NP_062729
Location (UCSC)	Chr X: 49.17 – 49.18 Mb	Chr X: 7.67 – 7.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000102007 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031146 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Oliva MM, Wu TC, Yang VW (May 1993). "Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18". Arch Biochem Biophys. 302 (1): 183–192. doi:10.1006/abbi.1993.1197. PMID 8470895.
6. Oliva MM, Cortese JF, Yang VW (Aug 1995). "Promoter regulation of a differentially expressed gene in the human colonic epithelial cell lines HT29-18 and HT29-18-C1". Gene. 159 (2): 151–157. doi:10.1016/0378-1119(95)00130-X. PMID 7622043.
7. "Entrez Gene: PLP2 proteolipid protein 2 (colonic epithelium-enriched)".

Further reading

• Breitwieser GE, McLenithan JC, Cortese JF, et al. (1997). "Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics". Am. J. Physiol. 272 (3 Pt 1): C957–65. doi:10.1152/ajpcell.1997.272.3.C957. PMID 9124532.
• Fisher SE, Ciccodicola A, Tanaka K, et al. (1998). "Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp" (PDF). Genomics. 45 (2): 340–347. doi:10.1006/geno.1997.4941. PMID 9344658.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang B, Nguyen M, Breckenridge DG, et al. (2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–14468. doi:10.1074/jbc.M209684200. PMID 12529377.
• Lee SM, Shin H, Jang SW, et al. (2004). "PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells". Biochem. Biophys. Res. Commun. 324 (2): 768–772. doi:10.1016/j.bbrc.2004.09.118. PMID 15474493.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–208. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
• Zhang L, Jie C, Obie C, et al. (2007). "X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation". Genome Res. 17 (5): 641–648. doi:10.1101/gr.5336307. PMC 1855181. PMID 17416750.
• Stirling PC, Srayko M, Takhar KS, et al. (2007). "Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression". Mol. Biol. Cell. 18 (6): 2336–2345. doi:10.1091/mbc.E07-01-0069. PMC 1877119. PMID 17429077.