PPFIBP1

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.[5][6][7]

PPFIBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TAD
Identifiers
Aliases	PPFIBP1, L2, SGT2, hSGT2, hSgt2p, PPFIA binding protein 1
External IDs	OMIM: 603141 MGI: 1914783 HomoloGene: 2685 GeneCards: PPFIBP1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.23-p11.22 Start 27,523,431 bp[1] End 27,695,564 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G3 Start 146,888,487 bp[2] End 147,032,025 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cadherin binding Cellular component • cell membrane • focal adhesion • cytosol Biological process • cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8496	67533
Ensembl	ENSG00000110841	ENSMUSG00000016487
UniProt	Q86W92	Q8C8U0
RefSeq (mRNA)	NM_001198915 NM_001198916 NM_003622 NM_177444	NM_001170433 NM_026221 NM_001355728 NM_001355729
RefSeq (protein)	NP_001185844 NP_001185845 NP_003613 NP_803193	NP_001163904 NP_080497 NP_001342657 NP_001342658
Location (UCSC)	Chr 12: 27.52 – 27.7 Mb	Chr 6: 146.89 – 147.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions

PPFIBP1 has been shown to interact with liprin-alpha-1.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000110841 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016487 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
6. Kriajevska M, Fischer-Larsen M, Moertz E, Vorm O, Tulchinsky E, Grigorian M, Ambartsumian N, Lukanidin E (Feb 2002). "Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1)". J Biol Chem. 277 (7): 5229–35. doi:10.1074/jbc.M110976200. PMID 11836260.
7. "Entrez Gene: PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. CiteSeerX 10.1.1.323.5263. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.