PPP1R10

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.[5][6][7]

PPP1R10
Identifiers
Aliases	PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99, protein phosphatase 1 regulatory subunit 10
External IDs	OMIM: 603771 MGI: 1289273 HomoloGene: 2033 GeneCards: PPP1R10
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,600,413 bp[1] End 30,618,612 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.77 cM Start 35,916,434 bp[2] End 35,932,283 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase inhibitor activity • DNA binding • metal ion binding • RNA binding • GO:0001948 protein binding Cellular component • chromatin • PTW/PP1 phosphatase complex • cell nucleus • nuclear chromosome, telomeric region • nucleoplasm • nuclear body Biological process • GO:0048553 negative regulation of catalytic activity • protein import into nucleus • negative regulation of cardiac muscle cell apoptotic process • positive regulation of telomere maintenance • negative regulation of phosphoprotein phosphatase activity • negative regulation of mitotic DNA damage checkpoint Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5514	52040
Ensembl	ENSG00000227804 ENSG00000238104 ENSG00000206489 ENSG00000230995 ENSG00000235291 ENSG00000231737 ENSG00000204569	ENSMUSG00000039220
UniProt	Q96QC0	Q80W00
RefSeq (mRNA)	NM_002714 NM_001376195	NM_001163818 NM_175934 NM_001357740
RefSeq (protein)	NP_002705 NP_001363124	NP_001157290 NP_001344669
Location (UCSC)	Chr 6: 30.6 – 30.62 Mb	Chr 17: 35.92 – 35.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.[7]

References

1. ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 GRCh38: Ensembl release 89: ENSG00000227804, ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039220 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi:10.1074/jbc.273.7.4089. PMID 9461602.
6. Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi:10.1006/bbrc.1998.9354. PMID 9784381.
7. "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

Further reading

• Totaro A, Rommens JM, Grifa A, et al. (1997). "Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region". Genomics. 31 (3): 319–26. doi:10.1006/geno.1996.0054. PMID 8838313.
• Kreivi JP, Trinkle-Mulcahy L, Lyon CE, et al. (1998). "Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity". FEBS Lett. 420 (1): 57–62. doi:10.1016/S0014-5793(97)01485-3. PMID 9450550. S2CID 23856958.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim YM, Watanabe T, Allen PB, et al. (2003). "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation". J. Biol. Chem. 278 (16): 13819–28. doi:10.1074/jbc.M209621200. PMID 12574161.
• Reeder JE, Sowden MP, Messing EM, et al. (2003). "Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line". Cancer Cell International. 3 (1): 12. doi:10.1186/1475-2867-3-12. PMC 183861. PMID 12914669.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Raha-Chowdhury R, Andrews SR, Gruen JR (2005). "CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease". Brain Res. Mol. Brain Res. 138 (1): 70–83. doi:10.1016/j.molbrainres.2005.04.001. PMID 15894402.
• Landsverk HB, Kirkhus M, Bollen M, et al. (2006). "PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner". Biochem. J. 390 (Pt 3): 709–17. doi:10.1042/BJ20050678. PMC 1199665. PMID 15907195.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Lee SJ, Lim CJ, Min JK, et al. (2007). "Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2". Cell Death Differ. 14 (6): 1106–16. doi:10.1038/sj.cdd.4402111. PMID 17318220.