PPP1R17

Protein phosphatase 1 regulatory subunit 17 is a protein that in humans is encoded by the PPP1R17 gene.[5][6][7]

PPP1R17
Identifiers
Aliases	PPP1R17, C7orf16, GSBS, protein phosphatase 1 regulatory subunit 17
External IDs	OMIM: 604088 MGI: 1333876 HomoloGene: 4849 GeneCards: PPP1R17
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 31,687,215 bp[1] End 31,708,455 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 27.65 cM Start 56,017,497 bp[2] End 56,032,689 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase inhibitor activity • protein serine/threonine phosphatase inhibitor activity • phosphatase inhibitor activity Cellular component • cellular component • nucleoplasm Biological process • regulation of phosphatase activity • central nervous system development • GO:0007243 intracellular signal transduction • GO:0048553 negative regulation of catalytic activity • negative regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10842	19051
Ensembl	ENSG00000106341	ENSMUSG00000002930
UniProt	O96001	Q9Z2E4
RefSeq (mRNA)	NM_001145123 NM_006658	NM_011153
RefSeq (protein)	NP_001138595 NP_006649	NP_035283
Location (UCSC)	Chr 7: 31.69 – 31.71 Mb	Chr 6: 56.02 – 56.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000106341 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002930 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M (Mar 1999). "Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2467–72. doi:10.1073/pnas.96.5.2467. PMC 26808. PMID 10051666.
6. Hall KU, Collins SP, Gamm DM, Massa E, DePaoli-Roach AA, Uhler MD (Feb 1999). "Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 274 (6): 3485–95. doi:10.1074/jbc.274.6.3485. PMID 9920894.
7. "Entrez Gene: C7orf16 chromosome 7 open reading frame 16".

External links

• Human PPP1R17 genome location and PPP1R17 gene details page in the UCSC Genome Browser.

Further reading

• Ono S, Ezura Y, Emi M, Fujita Y, Takada D, Sato K, Ishigami T, Umemura S, Takahashi K, Kamimura K, Bujo H, Saito Y (2003). "A promoter SNP (-1323T>C) in G-substrate gene (GSBS) correlates with hypercholesterolemia". Journal of Human Genetics. 48 (9): 447–50. doi:10.1007/s10038-003-0055-x. PMID 12955585.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.