PPP2R2D

PP2A subunit B isoform delta also known as serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform is a protein that in humans is encoded by the PPP2R2D gene.[5] It is a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.

PPP2R2D
Identifiers
Aliases	PPP2R2D, MDS026, protein phosphatase 2 regulatory subunit Bdelta, B55delta, B55D
External IDs	OMIM: 613992 MGI: 1289252 HomoloGene: 81915 GeneCards: PPP2R2D
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 131,901,008 bp[1] End 131,959,834 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F4|7 82.95 cM Start 138,846,079 bp[2] End 138,883,057 bp[2]
Gene ontology Molecular function • protein serine/threonine phosphatase activity • GO:0001948 protein binding • protein phosphatase regulator activity Cellular component • cytoplasm • protein phosphatase type 2A complex • cytosol Biological process • cell division • cell cycle • exit from mitosis • peptidyl-serine dephosphorylation • GO:0007067 mitotic cell cycle • developmental process • regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55844	52432
Ensembl	ENSG00000175470	ENSMUSG00000041769
UniProt	Q66LE6	Q925E7
RefSeq (mRNA)	NM_001003656 NM_001291310 NM_018461	NM_026391 NM_001347618
RefSeq (protein)	NP_001278239 NP_060931	NP_001334547 NP_080667
Location (UCSC)	Chr 10: 131.9 – 131.96 Mb	Chr 7: 138.85 – 138.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000175470 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041769 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Protein phosphatase 2 regulatory subunit Bdelta".

Further reading

• Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M (September 2008). "Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling". Development. 135 (17): 2927–37. doi:10.1242/dev.020842. PMC 4940033. PMID 18697906.
• Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN, Lin YC (2012). "Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene". PLOS ONE. 7 (4): e35524. doi:10.1371/journal.pone.0035524. PMC 3335092. PMID 22539979.