PPP2R3B

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.[3][4]

PPP2R3B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4I5L, 4I5N, 4MEW
Identifiers
Aliases	PPP2R3B, NYREN8, PPP2R3L, PPP2R3LY, PR48, protein phosphatase 2 regulatory subunit Bbeta, PR70
External IDs	OMIM: 300339 HomoloGene: 61474 GeneCards: PPP2R3B
Gene location (Human) Chr. X chromosome (human)[1] Band X;Y Start 333,933 bp[1] End 386,955 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • protein serine/threonine phosphatase activity • phosphoprotein phosphatase activity • GO:0001948 protein binding • metal ion binding • protein phosphatase regulator activity Cellular component • protein phosphatase type 2A complex • cell nucleus • nucleoplasm Biological process • protein dephosphorylation • cell cycle arrest • regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28227	n/a
Ensembl	ENSG00000276438 ENSG00000273850 ENSG00000167393	n/a
UniProt	Q9Y5P8	n/a
RefSeq (mRNA)	NM_013239 NM_199326	n/a
RefSeq (protein)	NP_037371	n/a
Location (UCSC)	Chr X: 0.33 – 0.39 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]

Interactions

PPP2R3B has been shown to interact with PPP2R1B,[5] PPP2R1A,[5][6] CDC6[7] and PPP2CA.[6][7]

References

1. ENSG00000273850, ENSG00000167393 GRCh38: Ensembl release 89: ENSG00000276438, ENSG00000273850, ENSG00000167393 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Schiebel K, Meder J, Rump A, Rosenthal A, Winkelmann M, Fischer C, Bonk T, Humeny A, Rappold G (February 2001). "Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region". Cytogenetics and Cell Genetics. 91 (1–4): 224–30. doi:10.1159/000056849. PMID 11173861.
4. "Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta".
5. Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal. 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.
6. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
7. Yan Z, Fedorov SA, Mumby MC, Williams RS (Feb 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology. 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ruediger R, Fields K, Walter G (Jan 1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". Journal of Virology. 73 (1): 839–42. PMC 103900. PMID 9847399.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Yan Z, Fedorov SA, Mumby MC, Williams RS (Feb 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology. 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.
• Yokoyama N, Miller WT (Sep 2001). "Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS)". Oncogene. 20 (42): 6057–65. doi:10.1038/sj.onc.1204735. PMID 11593413.
• Stevens I, Janssens V, Martens E, Dilworth S, Goris J, Van Hoof C (Jan 2003). "Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues". European Journal of Biochemistry / FEBS. 270 (2): 376–87. doi:10.1046/j.1432-1033.2003.03398.x. PMID 12605688.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gao Y, Kitagawa K, Hiramatsu Y, Kikuchi H, Isobe T, Shimada M, Uchida C, Hattori T, Oda T, Nakayama K, Nakayama KI, Tanaka T, Konno H, Kitagawa M (Dec 2006). "Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis". Cancer Research. 66 (24): 11623–31. doi:10.1158/0008-5472.CAN-06-2629. PMID 17178856.