PREPL

Prolyl endopeptidase-like is an enzyme that in humans is encoded by the PREPL gene.[5][6]

PREPL
Identifiers
Aliases	PREPL, prolyl endopeptidase-like, CMS22, prolyl endopeptidase like
External IDs	OMIM: 609557 MGI: 2441932 HomoloGene: 15481 GeneCards: PREPL
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 44,316,281 bp[1] End 44,361,862 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 85,063,470 bp[2] End 85,090,241 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • serine-type exopeptidase activity • peptidase activity • serine-type peptidase activity • hydrolase activity • serine-type endopeptidase activity • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • Golgi apparatus • cytoskeleton Biological process • proteolysis • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9581	213760
Ensembl	ENSG00000138078	ENSMUSG00000024127
UniProt	Q4J6C6	Q8C167
RefSeq (mRNA)	NM_001042385 NM_001042386 NM_001171603 NM_001171606 NM_001171613 NM_001171617 NM_006036 NM_001374275 NM_001374276 NM_001374277	NM_001163622 NM_001163623 NM_001163624 NM_145984
RefSeq (protein)	NP_001035844 NP_001035845 NP_001165074 NP_001165077 NP_001165084 NP_001165088 NP_006027 NP_001361204 NP_001361205 NP_001361206	NP_001157094 NP_001157095 NP_001157096 NP_666096
Location (UCSC)	Chr 2: 44.32 – 44.36 Mb	Chr 17: 85.06 – 85.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

PREPL belongs to the prolyloligopeptidase subfamily of serine peptidases (Parvari et al., 2005).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000138078 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024127 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (Sep 2001). "A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease". Am J Hum Genet. 69 (4): 869–875. doi:10.1086/323624. PMC 1226072. PMID 11524703.
6. "Entrez Gene: PREPL prolyl endopeptidase-like".

Further reading

• Martens K, Derua R, Meulemans S, et al. (2006). "PREPL: a putative novel oligopeptidase propelled into the limelight". Biol. Chem. 387 (7): 879–883. doi:10.1515/BC.2006.111. PMID 16913837. S2CID 7983864.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Kim DK, Kanai Y, Choi HW, et al. (2002). "Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells". Biochim. Biophys. Acta. 1565 (1): 112–122. doi:10.1016/S0005-2736(02)00516-3. PMID 12225859.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Parvari R, Gonen Y, Alshafee I, et al. (2005). "The 2p21 deletion syndrome: characterization of the transcription content". Genomics. 86 (2): 195–211. doi:10.1016/j.ygeno.2005.04.001. PMID 15913950.
• Szeltner Z, Alshafee I, Juhász T, et al. (2005). "The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity". Cell. Mol. Life Sci. 62 (19–20): 2376–2381. doi:10.1007/s00018-005-5262-5. PMID 16143824. S2CID 11081394.
• Jaeken J, Martens K, Francois I, et al. (2006). "Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome". Am. J. Hum. Genet. 78 (1): 38–51. doi:10.1086/498852. PMC 1380222. PMID 16385448.