PRIC285

Peroxisomal proliferator-activated receptor A interacting complex 285, also known as PRIC285, is a human gene.[5]

HELZ2
Identifiers
Aliases	HELZ2, PDIP-1, PRIC285, helicase with zinc finger 2
External IDs	OMIM: 611265 MGI: 2385169 HomoloGene: 14118 GeneCards: HELZ2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,558,086 bp[1] End 63,574,239 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 181,227,615 bp[2] End 181,242,027 bp[2]
Gene ontology Molecular function • DNA binding • nucleotide binding • GO:0001948 protein binding • ATP binding • hydrolase activity • GO:0008026 helicase activity • ligand-dependent nuclear receptor transcription coactivator activity • metal ion binding • RNA binding • ribonuclease activity Cellular component • membrane • cell nucleus • nucleoplasm • cytoplasm Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of lipid metabolic process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85441	229003
Ensembl	ENSG00000130589	ENSMUSG00000027580
UniProt	Q9BYK8	E9QAM5
RefSeq (mRNA)	NM_001037335 NM_033405	NM_183162
RefSeq (protein)	NP_001032412 NP_208384	NP_898985
Location (UCSC)	Chr 20: 63.56 – 63.57 Mb	Chr 2: 181.23 – 181.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000130589 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027580 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.