PTBP2

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.[5][6]

PTBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQ1, 2MJU, 4CQ1
Identifiers
Aliases	PTBP2, PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2
External IDs	OMIM: 608449 MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.3 Start 96,721,665 bp[1] End 96,823,738 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 119,718,742 bp[2] End 119,784,466 bp[2]
Gene ontology Molecular function • mRNA binding • pre-mRNA binding • nucleic acid binding • RNA binding Cellular component • growth cone • spliceosomal complex • neuronal cell body • cell nucleus Biological process • mRNA splice site selection • cerebellum development • mRNA processing • RNA splicing • spinal cord development • regulation of neural precursor cell proliferation • negative regulation of RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	58155	56195
Ensembl	ENSG00000117569	ENSMUSG00000028134
UniProt	Q9UKA9	Q91Z31
RefSeq (mRNA)	NM_001300985 NM_001300986 NM_001300987 NM_001300988 NM_001300989 NM_001300990 NM_021190	NM_019550 NM_001310711
RefSeq (protein)	NP_001287914 NP_001287915 NP_001287916 NP_001287917 NP_001287918 NP_001287919 NP_067013	NP_001297640 NP_062423
Location (UCSC)	Chr 1: 96.72 – 96.82 Mb	Chr 3: 119.72 – 119.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000117569 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028134 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
6. "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.