PYGO2

Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.[5][6]

PYGO2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2XB1, 4UP0, 4UP5
Identifiers
Aliases	PYGO2, 1190004M21Rik, pygopus family PHD finger 2
External IDs	OMIM: 606903 MGI: 1916161 HomoloGene: 44519 GeneCards: PYGO2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 154,957,026 bp[1] End 154,963,853 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 89,430,214 bp[2] End 89,435,128 bp[2]
Gene ontology Molecular function • histone binding • metal ion binding • GO:0001948 protein binding • chromatin binding • histone acetyltransferase regulator activity Cellular component • nucleoplasm • cell nucleus • beta-catenin-TCF complex Biological process • palate development • regulation of histone H3-K4 methylation • in utero embryonic development • regulation of mammary gland epithelial cell proliferation • positive regulation of chromatin binding • mammary gland development • brain development • lens development in camera-type eye • developmental growth • regulation of histone acetylation • spermatid development • canonical Wnt signaling pathway • beta-catenin-TCF complex assembly • kidney development • spermatid nucleus differentiation • post-embryonic development • Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90780	68911
Ensembl	ENSG00000163348	ENSMUSG00000047824
UniProt	Q9BRQ0	n/a
RefSeq (mRNA)	NM_138300	NM_001293763 NM_001293766 NM_001293767 NM_001293768 NM_026869
RefSeq (protein)	NP_612157	n/a
Location (UCSC)	Chr 1: 154.96 – 154.96 Mb	Chr 3: 89.43 – 89.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163348 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047824 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (May 2002). "A new nuclear component of the Wnt signalling pathway". Nat Cell Biol. 4 (5): 367–73. doi:10.1038/ncb786. PMID 11988739. S2CID 23942463.
6. "Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila)".

Further reading

• Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex" (PDF). Cell. 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446. S2CID 16720801.
• Pilvar P, Chalbatani GM, Forghanifard MM, Mahmoodzadeh H, Besanjideh P (2017). "The evaluation of SALL4 gene silencing, and effects on PYGO2, twist and maml genes in esophageal squamous cell carcinoma". Int J Pharm Sci Res. 8 (7): 1000–07. doi:10.13040/IJPSR.0975-8232.8(7).1000-07 (inactive 2021-01-31).CS1 maint: DOI inactive as of January 2021 (link)
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447. S2CID 6880212.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Popadiuk CM, Xiong J, Wells MG, et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer". Clin. Cancer Res. 12 (7 Pt 1): 2216–23. doi:10.1158/1078-0432.CCR-05-2433. PMID 16609037. S2CID 3260972.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272. S2CID 17642255.
• Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer". Int. J. Oncol. 30 (2): 357–63. doi:10.3892/ijo.30.2.357 (inactive 2021-01-31). PMID 17203217.CS1 maint: DOI inactive as of January 2021 (link)