Paul Sigler

Paul B. Sigler (February 19, 1934 – January 11, 2000[7][1]) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University.[3][8] Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim[2] and Helen Hay Whitney Fellowships.[5] He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others.[1]

Paul B. Sigler
Born	February 19, 1934[1] Richmond, Virginia, US[2]
Died	January 11, 2000 (aged 65)[1] New Haven, Connecticut, US[2]
Monuments	Memorial plaque on Science Hill (Yale University) Lewis-Sigler Institute for Integrative Genomics at Princeton University
Nationality	American
Occupation	Professor[3]
Spouse(s)	Althea Jo Martin Sigler[2]
Children	5 children[2]
Alma mater	Princeton University Columbia University (MD) Cambridge University (PhD)[2]
Known for	Phospholipase A2 trp repressor[1]
Awards	National Academy of Sciences[2] HHMI Investigator[4] Guggenheim Fellow[2] Helen Hay Whitney Fellow[5]
Scientific career
Fields	Biophysics Biochemistry[3]
Institutions	Yale University[3] University of Chicago MRC-LMB NIH[2]
Doctoral advisors	David M. Blow[6]
Website	www.hhmi.org/scientists/paul-b-sigler

Biography

Prior to coming to Yale, he was a professor at the University of Chicago.[2] He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955.[2] After briefly practicing medicine and working as a researcher for the NIH,[5] he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology[2] working under David M. Blow[6] before moving to the University of Chicago.[2]

Memorials

A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry.[9] Yale also has sponsored Paul Sigler memorial symposia in the past.[10] The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.[11]

Death

Paul Sigler died on January 11, 2000 at New Haven, Connecticut, US, 39 days before his 66th birthday.

Selected publications

• Lambright, David G.; Sondek, John; Bohm, Andrew; Skiba, Nikolai P.; Hamm, Heidi E.; Sigler, Paul B. (1996). "The 2.0 Å crystal structure of a heterotrimeric G protein". Nature. 379 (6563): 311–9. Bibcode:1996Natur.379..311L. doi:10.1038/379311a0. PMID 8552184. S2CID 4350943.
• Luisi, B. F.; Xu, W. X.; Otwinowski, Z.; Freedman, L. P.; Yamamoto, K. R.; Sigler, P. B. (1991). "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA". Nature. 352 (6335): 497–505. Bibcode:1991Natur.352..497L. doi:10.1038/352497a0. PMID 1865905. S2CID 1919276.
• Braig, Kerstin; Otwinowski, Zbyszek; Hegde, Rashmi; Boisvert, David C.; Joachimiak, Andrzej; Horwich, Arthur L.; Sigler, Paul B. (1994). "The crystal structure of the bacterial chaperonln GroEL at 2.8 Å". Nature. 371 (6498): 578–86. Bibcode:1994Natur.371..578B. doi:10.1038/371578a0. PMID 7935790. S2CID 4341993.
• Kim, Youngchang; Geiger, James. H.; Hahn, Steven; Sigler, Paul B. (1993). "Crystal structure of a yeast TBP/TATA-box complex". Nature. 365 (6446): 512–20. Bibcode:1993Natur.365..512K. doi:10.1038/365512a0. PMID 8413604. S2CID 4336203.
• Vinson, C.; Sigler, P.; McKnight, S. (1989). "Scissors-grip model for DNA recognition by a family of leucine zipper proteins". Science. 246 (4932): 911–6. Bibcode:1989Sci...246..911V. doi:10.1126/science.2683088. PMID 2683088.
• Otwinowski, Z; Schevitz, R. W.; Zhang, R. G.; Lawson, C. L.; Joachimiak, A; Marmorstein, R. Q.; Luisi, B. F.; Sigler, P. B. (1988). "Crystal structure of trp repressor/operator complex at atomic resolution". Nature. 335 (6188): 321–9. Bibcode:1988Natur.335..321O. doi:10.1038/335321a0. PMID 3419502. S2CID 9358980.

See also

• List of Guggenheim Fellowships awarded in 1974
• List of University of Chicago people

References

1. "(IUCr) Paul B. Sigler (1934-2000)".
2. "New York Times Obit".
3. "Yale University Press Release".
4. "Paul B. Sigler, MD, PhD - HHMI.org". HHMI.org.
5. "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
6. "Blow on AcademicTree.org".
7. National Academy of Sciences
8. "Official Site".
9. Paul Sigler Memorial
10. "Paul Sigler Symposium".
11. "Helen Hay Whitney Foundation - Announcement".

Further reading

• "New York Times Obit".
• "Yale obit".
• "(IUCr) Paul B. Sigler (1934-2000)".
• "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
• Brian W. Matthews (2000). "Obituary: Paul Sigler (1934–2000)". Nature. 403 (6772): 848. Bibcode:2000Natur.403..848M. doi:10.1038/35002722. PMID 10706270. S2CID 205004640.
• Henderson, Richard (2000). "Paul Sigler: A structural biologist with passion". Nature Structural Biology. 7 (4): 271–272. doi:10.1038/74024. S2CID 34789342.
• Jeruzalmi, David; Kuriyan, John; Doudna, Jennifer (2000). "Paul Sigler (1934–2000)". Trends in Biochemical Sciences. 25 (5): 221–2. doi:10.1016/S0968-0004(00)01587-5. PMID 10782089.
• Horwich, A; Joachimiak, A (2000). "Paul Sigler (1934–2000)". Protein Science. 9 (4): 827–828. PMC 2144625.
• Perutz, Max (2000). "Paul Sigler (1934–2000)". Cell. 101 (1): 23–4. doi:10.1016/S0092-8674(02)71111-2. PMID 10778852.
• Davies, David R (2000). "Obituary: Paul Sigler". Structure. 8 (3): R67–8. doi:10.1016/S0969-2126(00)00113-1. PMID 10745016.

External links

• Official website at HHMI
• Paul B. Sigler on AcademicTree