Phthalide
Phthalide is an organic chemical compound with the molecular formula C8H6O2. It is a lactone that serves as the core chemical structure for a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).
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| Names | |
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| IUPAC name
2-Benzofuran-1(3H)-one | |
| Other names
Phthalolactone | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.001.586  |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C8H6O2 | |
| Molar mass | 134.134 g·mol−1 |
| Melting point | 75 to 77 °C (167 to 171 °F; 348 to 350 K)[1] |
| Boiling point | 290 °C (554 °F; 563 K)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Uses
Phthalide is used in the synthesis of several pharmaceutical drugs including isoxepac, vatalanib, and hydralazine as well as the pesticide kresoxim-methyl.
Versatile material, can be used for e.g. pipethiadene, etc..
Examples
Phenolphthalein
Tetrachlorophthalide
References
- Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi, C.; Reddy, K. Rajender (2011). "Synthesis of 3H-Quinazolin-4-ones and 4H-3,1-Benzoxazin-4-ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide-tert-Butyl Hydroperoxide". Advanced Synthesis & Catalysis. 353 (2+3): 401–410. doi:10.1002/adsc.201000580.
- Kus, Nermin Simsek (2008). "Some oxidation reactions with molecular oxygen in subcritical water". Asian Journal of Chemistry. 20 (2): 1226–1230.
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