Pyroglutamyl-peptidase II
Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides
| Pyroglutamyl-peptidase II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.19.6 | ||||||||
| CAS number | 60063-88-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is highly specific for thyrotropin releasing hormone.
Human gene
TRHDE - thyrotropin releasing hormone degrading enzyme
References
- Bauer K, Nowak P (September 1979). "Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond". European Journal of Biochemistry. 99 (2): 239–46. doi:10.1111/j.1432-1033.1979.tb13250.x. PMID 115687.
- O'Connor B, O'Cuinn G (July 1985). "Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain". European Journal of Biochemistry. 150 (1): 47–52. doi:10.1111/j.1432-1033.1985.tb08986.x. PMID 2862039.
- Wilk, S.; Wilk, E.K. (1989). "Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme". Neurochem. Int. 15: 81–89. doi:10.1016/0197-0186(89)90079-x.
External links
- Pyroglutamyl-peptidase+II at the US National Library of Medicine Medical Subject Headings (MeSH)
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