RAB4A

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.[5]

RAB4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YU9, 1Z0K, 2BMD, 2BME
Identifiers
Aliases	RAB4A, HRES-1, HRES-1/RAB4, HRES1, RAB4, member RAS oncogene family
External IDs	OMIM: 179511 MGI: 105069 HomoloGene: 101538 GeneCards: RAB4A
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 229,271,062 bp[1] End 229,305,894 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E2|8 72.19 cM Start 123,805,985 bp[2] End 123,835,287 bp[2]
Gene ontology Molecular function • nucleotide binding • GDP binding • ATPase binding • GTP binding • GO:0001948 protein binding • GTPase activity • ATPase activator activity • syntaxin binding • ionotropic glutamate receptor binding Cellular component • cytoplasm • recycling endosome • vesicle • cytosol • endosome • membrane • intracellular membrane-bounded organelle • insulin-responsive compartment • cell membrane • perinuclear region of cytoplasm • extracellular exosome • cytoplasmic vesicle membrane • postsynaptic recycling endosome • early endosome membrane • recycling endosome membrane • anchored component of synaptic vesicle membrane Biological process • regulation of endocytosis • antigen processing and presentation • positive regulation of ATPase activity • Rab protein signal transduction • protein transport • phosphatidylinositol biosynthetic process • intracellular protein transport • small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5867	19341
Ensembl	ENSG00000168118	ENSMUSG00000019478
UniProt	P20338	P56371
RefSeq (mRNA)	NM_001271998 NM_004578	NM_009003
RefSeq (protein)	NP_001258927 NP_004569 NP_004569.2	NP_033029
Location (UCSC)	Chr 1: 229.27 – 229.31 Mb	Chr 8: 123.81 – 123.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RAB4A has been shown to interact with:

• CD2AP,[6]
• KIF3B,[7]
• RAB11FIP1,[8]
• RABEP1,[9] and
• STX4.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000168118 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019478 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAB4A RAB4A, member RAS oncogene family".
6. Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (Feb 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic. 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. PMID 12559036.
7. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM (Jul 2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin". Molecular and Cellular Biology. 23 (14): 4892–900. doi:10.1128/mcb.23.14.4892-4900.2003. PMC 162221. PMID 12832475.
8. Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". The Journal of Biological Chemistry. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
9. Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC 1170540. PMID 9524117.
10. Li L, Omata W, Kojima I, Shibata H (Feb 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry. 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.

Further reading

• Stibbs HH, Seed JR (Apr 1975). "Short-term metabolism of (14-C) tryptophan in rats infected with Trypanosoma brucei gambiense". The Journal of Infectious Diseases. 131 (4): 459–62. doi:10.1093/infdis/131.4.459. PMID 1117200.
• van der Sluijs P, Hull M, Huber LA, Mâle P, Goud B, Mellman I (Dec 1992). "Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle". The EMBO Journal. 11 (12): 4379–89. doi:10.1002/j.1460-2075.1992.tb05538.x. PMC 557012. PMID 1425574.
• Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M (Apr 1991). "Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2". Nature. 350 (6320): 715–8. doi:10.1038/350715a0. PMID 1902553.
• Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R (Feb 1991). "Chromosome assignment of four RAS-related RAB genes". Human Genetics. 86 (4): 350–4. doi:10.1007/BF00201831. PMID 1999336.
• Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry. 264 (21): 12394–401. PMID 2501306.
• Cormont M, Tanti JF, Zahraoui A, Van Obberghen E, Le Marchand-Brustel Y (Feb 1994). "Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1". European Journal of Biochemistry / FEBS. 219 (3): 1081–5. doi:10.1111/j.1432-1033.1994.tb18591.x. PMID 8112321.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Karniguian A, Zahraoui A, Tavitian A (Aug 1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7647–51. doi:10.1073/pnas.90.16.7647. PMC 47199. PMID 8356066.
• Valentijn JA, LaCivita DQ, Gumkowski FD, Jamieson JD (Jan 1997). "Rab4 associates with the actin terminal web in developing rat pancreatic acinar cells". European Journal of Cell Biology. 72 (1): 1–8. PMID 9013719.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC 1170540. PMID 9524117.
• Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (May 1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
• Shisheva A, Chinni SR, DeMarco C (Sep 1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry. 38 (36): 11711–21. doi:10.1021/bi990200r. PMID 10512627.
• Nagelkerken B, Van Anken E, Van Raak M, Gerez L, Mohrmann K, Van Uden N, Holthuizen J, Pelkmans L, Van Der Sluijs P (Mar 2000). "Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles". The Biochemical Journal. 346 (3): 593–601. doi:10.1042/0264-6021:3460593. PMC 1220890. PMID 10698684.
• Gerez L, Mohrmann K, van Raak M, Jongeneelen M, Zhou XZ, Lu KP, van Der Sluijs P (Jul 2000). "Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase pin1 during mitosis". Molecular Biology of the Cell. 11 (7): 2201–11. doi:10.1091/mbc.11.7.2201. PMC 14913. PMID 10888662.
• Li L, Omata W, Kojima I, Shibata H (Feb 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry. 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (Feb 2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
• Bielli A, Thörnqvist PO, Hendrick AG, Finn R, Fitzgerald K, McCaffrey MW (Mar 2001). "The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1". Biochemical and Biophysical Research Communications. 281 (5): 1141–53. doi:10.1006/bbrc.2001.4468. PMID 11243854.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.