RAB5B

Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.[5][6][7]

RAB5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HEI
Identifiers
Aliases	RAB5B, Rab-5B, member RAS oncogene family
External IDs	OMIM: 179514 MGI: 105938 HomoloGene: 104027 GeneCards: RAB5B
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 55,973,913 bp[1] End 55,996,683 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,677,175 bp[2] End 128,696,264 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GDP binding • GTP binding • GTP-dependent protein binding • GO:0001948 protein binding • GTPase activity Cellular component • endosome • membrane • melanosome • endocytic vesicle • intracellular • early endosome • extracellular exosome • cell membrane • secretory granule membrane • early endosome membrane • intracellular membrane-bounded organelle • anchored component of synaptic vesicle membrane Biological process • regulation of endocytosis • antigen processing and presentation • endosome organization • plasma membrane to endosome transport • protein transport • neutrophil degranulation • transport • intracellular protein transport • Rab protein signal transduction • endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5869	19344
Ensembl	ENSG00000111540	ENSMUSG00000000711
UniProt	P61020	P61021
RefSeq (mRNA)	NM_001252036 NM_001252037 NM_002868	NM_011229 NM_177411
RefSeq (protein)	NP_001238965 NP_001238966 NP_002859	NP_803130
Location (UCSC)	Chr 12: 55.97 – 56 Mb	Chr 10: 128.68 – 128.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000111540 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000711 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilson DB, Wilson MP (Apr 1992). "Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases". J Clin Invest. 89 (3): 996–1005. doi:10.1172/JCI115683. PMC 442949. PMID 1541686.
6. Chiariello M, Bruni CB, Bucci C (Aug 1999). "The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro". FEBS Lett. 453 (1–2): 20–4. doi:10.1016/S0014-5793(99)00686-9. PMID 10403367. S2CID 30308802.
7. "Entrez Gene: RAB5B RAB5B, member RAS oncogene family".

Further reading

• Bucci C, Lütcke A, Steele-Mortimer O, Olkkonen VM, Dupree P, Chiariello M, Bruni CB, Simons K, Zerial M (1995). "Co-operative regulation of endocytosis by three Rab5 isoforms". FEBS Lett. 366 (1): 65–71. doi:10.1016/0014-5793(95)00477-Q. PMID 7789520. S2CID 40284549.
• Korenberg JR, Chen XN, Adams MD, Venter JC (1996). "Toward a cDNA map of the human genome". Genomics. 29 (2): 364–70. doi:10.1006/geno.1995.9993. PMID 8666383.
• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381.
• Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H (1999). "Direct interaction of EEA1 with Rab5b". Eur. J. Biochem. 265 (1): 361–6. doi:10.1046/j.1432-1327.1999.00743.x. PMID 10491193.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1". Dev. Cell. 1 (1): 73–82. doi:10.1016/S1534-5807(01)00008-9. PMID 11703925.
• Saito K, Murai J, Kajiho H, Kontani K, Kurosu H, Katada T (2002). "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5". J. Biol. Chem. 277 (5): 3412–8. doi:10.1074/jbc.M106276200. PMID 11733506.
• Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
• Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, Katada T (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Hirota Y, Kuronita T, Fujita H, Tanaka Y (2007). "A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments". Biochem. Biophys. Res. Commun. 364 (1): 40–7. doi:10.1016/j.bbrc.2007.09.089. PMID 17927960.