RAB5C

Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene.[5][6] RAB5C belongs to the Ras-related protein family.

RAB5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KYI
Identifiers
Aliases	RAB5C, L1880, RAB5CL, RAB5L, RABL, member RAS oncogene family
External IDs	OMIM: 604037 MGI: 105306 HomoloGene: 55533 GeneCards: RAB5C
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,124,976 bp[1] End 42,155,044 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.54 cM Start 100,715,009 bp[2] End 100,738,215 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • GDP binding • GTPase activity Cellular component • melanosome • lysosomal membrane • endosome • lipid droplet • endocytic vesicle • early endosome • extracellular exosome • membrane • cell membrane • early endosome membrane • azurophil granule membrane • cytoplasmic vesicle • anchored component of synaptic vesicle membrane • intracellular Biological process • protein transport • regulation of endocytosis • plasma membrane to endosome transport • neutrophil degranulation • transport • intracellular protein transport • Rab protein signal transduction • small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5878	19345
Ensembl	ENSG00000108774	ENSMUSG00000019173
UniProt	P51148	P35278
RefSeq (mRNA)	NM_001252039 NM_004583 NM_201434	NM_024456 NM_001305003
RefSeq (protein)	NP_001238968 NP_004574 NP_958842	NP_001291932 NP_077776
Location (UCSC)	Chr 17: 42.12 – 42.16 Mb	Chr 11: 100.72 – 100.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000108774 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019173 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1–2): 137–9. doi:10.1159/000134325. PMID 8646882.
6. "Entrez Gene: RAB5C RAB5C, member RAS oncogene family".

Further reading

• Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID 7951316. S2CID 11075629.
• Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells". J. Biol. Chem. 273 (51): 33901–4. doi:10.1074/jbc.273.51.33901. PMID 9852039.
• Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
• Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate". Infect. Immun. 68 (5): 2671–84. doi:10.1128/IAI.68.5.2671-2684.2000. PMC 97474. PMID 10768959.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
• Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.