RAB7B

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[5]

RAB7B
Identifiers
Aliases	RAB7B, RAB7, member RAS oncogene family
External IDs	MGI: 2442295 HomoloGene: 64833 GeneCards: RAB7B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,976,740 bp[1] End 206,003,461 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 131,688,695 bp[2] End 131,715,439 bp[2]
Gene ontology Molecular function • nucleotide binding • GTP binding • GTPase activity Cellular component • endosome • late endosome • Golgi apparatus • trans-Golgi network • lysosome • phagocytic vesicle membrane • phagocytic vesicle • membrane • cytoplasmic vesicle • late endosome membrane • vacuolar membrane Biological process • protein transport • negative regulation of toll-like receptor 9 signaling pathway • late endosome to Golgi transport • positive regulation of NF-kappaB transcription factor activity • positive regulation of megakaryocyte differentiation • negative regulation of toll-like receptor 4 signaling pathway • positive regulation of interleukin-6 production • cellular response to interferon-gamma • intracellular protein transport • endosome to lysosome transport • Rab protein signal transduction • phagosome-lysosome fusion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	338382	226421
Ensembl	ENSG00000276600	ENSMUSG00000052688
UniProt	Q96AH8	Q8VEA8
RefSeq (mRNA)	NM_001164522 NM_001304839 NM_177403	NM_145509 NM_001311096
RefSeq (protein)	NP_001157994 NP_001291768 NP_796377	NP_001298025 NP_663484
Location (UCSC)	Chr 1: 205.98 – 206 Mb	Chr 1: 131.69 – 131.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000276600 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052688 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID 15144907.
6. Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID 17395780.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.