RAB8B

Ras-related protein Rab-8B is a protein that in humans is encoded by the RAB8B gene.[5][6][7]

RAB8B
Identifiers
Aliases	RAB8B, member RAS oncogene family
External IDs	OMIM: 613532 MGI: 2442982 HomoloGene: 69220 GeneCards: RAB8B
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.2 Start 63,189,560 bp[1] End 63,267,776 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 66,843,664 bp[2] End 66,919,687 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleotide binding • receptor binding • GTP binding • TPR domain binding • GDP binding • GTPase activity Cellular component • mitochondrion • peroxisomal membrane • cell tip • membrane • phagocytic vesicle membrane • perinuclear region of cytoplasm • cytoplasmic vesicle • phagocytic vesicle • extracellular exosome • nucleoplasm • nuclear body • intracellular membrane-bounded organelle • recycling endosome membrane • endosome • cell membrane • synaptic vesicle • secretory granule membrane • trans-Golgi network transport vesicle • presynapse Biological process • vesicle docking involved in exocytosis • protein secretion • positive regulation of cell projection organization • protein import into peroxisome membrane • antigen processing and presentation • adherens junction organization • positive regulation of corticotropin secretion • protein transport • cilium morphogenesis • protein localization to plasma membrane • regulation of exocytosis • transport • intracellular protein transport • Rab protein signal transduction • cellular response to insulin stimulus • Golgi vesicle fusion to target membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51762	235442
Ensembl	ENSG00000166128	ENSMUSG00000036943
UniProt	Q92930	P61028
RefSeq (mRNA)	NM_016530	NM_173413
RefSeq (protein)	NP_057614	NP_775589
Location (UCSC)	Chr 15: 63.19 – 63.27 Mb	Chr 9: 66.84 – 66.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000166128 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036943 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen D, Guo J, Gahl WA (Mar 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
6. Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N (Nov 2008). "Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form". Hum Mol Genet. 17 (23): 3814–21. doi:10.1093/hmg/ddn279. PMID 18772196.
7. "Entrez Gene: RAB8B RAB8B, member RAS oncogene family".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lau AS, Mruk DD (2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hattula K, Furuhjelm J, Arffman A, Peränen J (2003). "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport". Mol. Biol. Cell. 13 (9): 3268–80. doi:10.1091/mbc.E02-03-0143. PMC 124888. PMID 12221131.
• de Bruyn KM, de Rooij J, Wolthuis RM, et al. (2000). "RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral". J. Biol. Chem. 275 (38): 29761–6. doi:10.1074/jbc.M001160200. PMID 10889189.
• Armstrong J, Thompson N, Squire JH, et al. (1997). "Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3". J. Cell Sci. 109 (6): 1265–74. PMID 8799816.