RABEPK

Rab9 effector protein with Kelch motifs also known as p40 is a protein that in humans is encoded by the RABEPK gene.[5][6]

RABEPK
Identifiers
Aliases	RABEPK, RAB9P40, bA65N13.1, p40, Rab9 effector protein with kelch motifs
External IDs	OMIM: 605962 MGI: 2139530 HomoloGene: 48772 GeneCards: RABEPK
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 125,200,542 bp[1] End 125,234,161 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 34,777,556 bp[2] End 34,799,912 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10244	227746
Ensembl	ENSG00000136933	ENSMUSG00000070953
UniProt	Q7Z6M1 Q5T1S5	Q8VCH5
RefSeq (mRNA)	NM_001174152 NM_001174153 NM_005833	NM_145522 NM_001374669
RefSeq (protein)	NP_001167623 NP_001167624 NP_005824	NP_663497 NP_001361598
Location (UCSC)	Chr 9: 125.2 – 125.23 Mb	Chr 2: 34.78 – 34.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Membrane-associated p40, in together with RAB9A, facilitates the transport of the mannose 6-phosphate receptor (MPR) from endosomes to the trans-Golgi network.[5]

Interactions

RABEPK has been shown to interact with RAB9A[5] and FYVE finger-containing phosphoinositide kinase.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000136933 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070953 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Diaz E, Schimmoller F, Pfeffer SR (Aug 1997). "A novel Rab9 effector required for endosome-to-TGN transport". J Cell Biol. 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071.
6. "Entrez Gene: RABEPK Rab9 effector protein with kelch motifs".
7. Ikonomov, Ognian C; Sbrissa Diego; Mlak Krzysztof; Deeb Robert; Fligger Jason; Soans Aleric; Finley Russell L; Shisheva Assia (Dec 2003). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. ISSN 0021-9258. PMID 14530284.

Further reading

• Aivazian D, Serrano RL, Pfeffer S (2006). "TIP47 is a key effector for Rab9 localization". J. Cell Biol. 173 (6): 917–26. doi:10.1083/jcb.200510010. PMC 2063917. PMID 16769818.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.
• Ikonomov OC, Sbrissa D, Mlak K, et al. (2004). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. PMID 14530284.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• RABEPK human gene location in the UCSC Genome Browser.
• RABEPK human gene details in the UCSC Genome Browser.