RASA4

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[5][6]

RASA4
Identifiers
Aliases	RASA4, CAPRI, GAPL, RAS p21 protein activator 4
External IDs	OMIM: 607943 MGI: 1858600 HomoloGene: 5080 GeneCards: RASA4
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 102,573,807 bp[1] End 102,616,757 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,083,916 bp[2] End 136,111,860 bp[2]
Gene ontology Molecular function • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • metal ion binding • phospholipid binding Cellular component • cytoplasm • cytosol • membrane • intrinsic component of the cytoplasmic side of the plasma membrane • cell membrane Biological process • GO:0007243 intracellular signal transduction • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • MAPK cascade • GO:0034259 negative regulation of GTPase activity • signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of Ras protein signal transduction • cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10156	54153
Ensembl	ENSG00000105808	ENSMUSG00000004952
UniProt	O43374	Q6PFQ7
RefSeq (mRNA)	NM_001079877 NM_006989	NM_001039103 NM_133914
RefSeq (protein)	NP_001073346 NP_008920	NP_001034192 NP_598675
Location (UCSC)	Chr 7: 102.57 – 102.62 Mb	Chr 5: 136.08 – 136.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105808 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004952 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol. 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776. S2CID 18141962.
6. "Entrez Gene: RASA4 RAS p21 protein activator 4".

Further reading

• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Minagawa T, Fukuda M, Mikoshiba K (2001). "Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538". Biochem. Biophys. Res. Commun. 288 (1): 87–90. doi:10.1006/bbrc.2001.5740. PMID 11594756.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu Q, Walker SA, Gao D, et al. (2005). "CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+". J. Cell Biol. 170 (2): 183–90. doi:10.1083/jcb.200504167. PMC 1351313. PMID 16009725.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• RASA4 human gene location in the UCSC Genome Browser.
• RASA4 human gene details in the UCSC Genome Browser.