RBM39

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.[5][6]

RBM39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JRS, 2MHN, 4OO6, 4OZ0, 4OZ1, 4YUD
Identifiers
Aliases	RBM39, CAPER, CAPERalpha, FSAP59, HCC1, RNPC2, RNA binding motif protein 39
External IDs	OMIM: 604739 MGI: 2157953 HomoloGene: 136465 GeneCards: RBM39
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 35,701,347 bp[1] End 35,742,312 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,147,239 bp[2] End 156,180,238 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleic acid binding • GO:0001948 protein binding • RNA binding Cellular component • microtubule cytoskeleton • cell nucleus • nucleoplasm • microtubule organizing center • nuclear speck • macromolecular complex Biological process • mRNA processing • RNA processing • regulation of transcription, DNA-templated • transcription, DNA-templated • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9584	170791
Ensembl	ENSG00000131051	ENSMUSG00000027620
UniProt	Q14498 Q5QP23	Q8VH51
RefSeq (mRNA)	NM_001242599 NM_001242600 NM_004902 NM_184234 NM_184237 NM_184241 NM_184244 NM_001323422 NM_001323423 NM_001323424	NM_001291114 NM_001291115 NM_133242 NM_001362763 NM_001362764 NM_001362765 NM_001362766 NM_001362767 NM_001362768 NM_001362769
RefSeq (protein)	NP_001229528 NP_001229529 NP_001310351 NP_001310352 NP_001310353 NP_004893 NP_909122	NP_001278043 NP_001278044 NP_573505 NP_001349692 NP_001349693 NP_001349694 NP_001349695 NP_001349696 NP_001349697 NP_001349698
Location (UCSC)	Chr 20: 35.7 – 35.74 Mb	Chr 2: 156.15 – 156.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[6]

Interactions

RBM39 has been shown to interact with Estrogen receptor alpha,[7] Estrogen receptor beta[7] and C-jun.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000131051 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027620 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest. 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425. PMID 8227358.
6. "Entrez Gene: RBM39 RNA binding motif protein 39".
7. Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.

Further reading

• Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW (2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta". Mol. Cell. 17 (3): 429–39. doi:10.1016/j.molcel.2004.12.025. PMID 15694343.
• Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.