RCC1

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.[5]

RCC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A12, 1I2M, 5E1O, 5E2A, 5E1M, 5E2B, 5E1D, 5E1B
Identifiers
Aliases	RCC1, CHC1, RCC1-I, SNHG3-regulator of chromosome condensation 1
External IDs	OMIM: 179710 MGI: 1913989 HomoloGene: 55567 GeneCards: RCC1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,505,943 bp[1] End 28,539,300 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,331,919 bp[2] End 132,353,605 bp[2]
Gene ontology Molecular function • DNA binding • guanyl-nucleotide exchange factor activity • histone binding • chromatin binding • GO:0001948 protein binding • nucleosomal DNA binding • Ran guanyl-nucleotide exchange factor activity • Ran GTPase binding • nucleosome binding • sulfate binding • protein heterodimerization activity Cellular component • cytoplasm • not the membrane • nucleoplasm • condensed nuclear chromosome • nuclear chromatin • cell nucleus • chromatin • chromosome • macromolecular complex Biological process • chromosome segregation • G1 phase • GO:0043148 mitotic spindle organization • cell division • spindle assembly • cell cycle • GO:0022415 viral process • regulation of mitotic nuclear division • protein heterotetramerization • regulation of molecular function • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1104	100088
Ensembl	ENSG00000180198	ENSMUSG00000028896
UniProt	P18754 Q5T081	Q8VE37
RefSeq (mRNA)	NM_001048194 NM_001048195 NM_001048199 NM_001269 NM_001381865 NM_001381866	NM_001197082 NM_133878
RefSeq (protein)	NP_001041659 NP_001041660 NP_001041664 NP_001260 NP_001368794 NP_001368795 NP_001041664.1 NP_001260.1	NP_001184011 NP_598639
Location (UCSC)	Chr 1: 28.51 – 28.54 Mb	Chr 4: 132.33 – 132.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.

Interactions

RCC1 has been shown to interact with RANBP3[6][7] and Ran (biology).[8][9][10][11]

References

1. GRCh38: Ensembl release 89: ENSG00000180198 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028896 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RCC1 Regulator of chromosome condensation 1".
6. Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". The Journal of Biological Chemistry. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. PMID 11932251.
7. Mueller L, Cordes VC, Bischoff FR, Ponstingl H (May 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Letters. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251.
8. Steggerda SM, Paschal BM (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". The Journal of Biological Chemistry. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. PMID 10811801.
9. Renault L, Kuhlmann J, Henkel A, Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. PMID 11336674.
10. Azuma Y, Renault L, García-Ranea JA, Valencia A, Nishimoto T, Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". Journal of Molecular Biology. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.
11. Ren M, Villamarin A, Shih A, Coutavas E, Moore MS, LoCurcio M, Clarke V, Oppenheim JD, D'Eustachio P, Rush MG (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Molecular and Cellular Biology. 15 (4): 2117–24. doi:10.1128/MCB.15.4.2117. PMC 230439. PMID 7891706.

Further reading

• Furuno N, Nakagawa K, Eguchi U, Ohtsubo M, Nishimoto T, Soeda E, Ohtubo M (October 1991). "Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis". Genomics. 11 (2): 459–61. doi:10.1016/0888-7543(91)90156-9. PMID 1769659.
• Bischoff FR, Ponstingl H (November 1991). "Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1". Nature. 354 (6348): 80–2. Bibcode:1991Natur.354...80B. doi:10.1038/354080a0. PMID 1944575.
• Bischoff FR, Ponstingl H (December 1991). "Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide". Proceedings of the National Academy of Sciences of the United States of America. 88 (23): 10830–4. Bibcode:1991PNAS...8810830B. doi:10.1073/pnas.88.23.10830. PMC 53025. PMID 1961752.
• Bischoff FR, Maier G, Tilz G, Ponstingl H (November 1990). "A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation". Proceedings of the National Academy of Sciences of the United States of America. 87 (21): 8617–21. Bibcode:1990PNAS...87.8617B. doi:10.1073/pnas.87.21.8617. PMC 55008. PMID 2236072.
• Ohtsubo M, Okazaki H, Nishimoto T (October 1989). "The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA". The Journal of Cell Biology. 109 (4 Pt 1): 1389–97. doi:10.1083/jcb.109.4.1389. PMC 2115805. PMID 2677018.
• Ohtsubo M, Kai R, Furuno N, Sekiguchi T, Sekiguchi M, Hayashida H, Kuma K, Miyata T, Fukushige S, Murotsu T (August 1987). "Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation". Genes & Development. 1 (6): 585–93. doi:10.1101/gad.1.6.585. PMID 3678831.
• Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (June 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Molecular & General Genetics. 247 (6): 661–9. doi:10.1007/BF00290397. PMID 7616957.
• Nishimoto T, Seino H, Seki N, Hori TA (October 1994). "The human CHC1 gene encoding RCC1 (regulator of chromosome condensation) (CHC1) is localized to human chromosome 1p36.1". Genomics. 23 (3): 719–21. doi:10.1006/geno.1994.1570. PMID 7851910.
• Miyabashira J, Sekiguchi T, Nishimoto T (August 1994). "Mammalian cells have two functional RCC1 proteins produced by alternative splicing". Journal of Cell Science. 107 ( Pt 8) (8): 2203–8. PMID 7983178.
• Noguchi E, Hayashi N, Azuma Y, Seki T, Nakamura M, Nakashima N, Yanagida M, He X, Mueller U, Sazer S, Nishimoto T (October 1996). "Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1". The EMBO Journal. 15 (20): 5595–605. doi:10.1002/j.1460-2075.1996.tb00944.x. PMC 452304. PMID 8896453.
• Renault L, Nassar N, Vetter I, Becker J, Klebe C, Roth M, Wittinghofer A (March 1998). "The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller". Nature. 392 (6671): 97–101. Bibcode:1998Natur.392...97R. doi:10.1038/32204. PMID 9510255.
• Renault L, Nassar N, Wittinghofer A, Roth M, Vetter IR (January 1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallographica. Section D, Biological Crystallography. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.
• Azuma Y, Renault L, García-Ranea JA, Valencia A, Nishimoto T, Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". Journal of Molecular Biology. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.
• Talcott B, Moore MS (April 2000). "The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip". The Journal of Biological Chemistry. 275 (14): 10099–104. doi:10.1074/jbc.275.14.10099. PMID 10744690.
• Nemergut ME, Macara IG (May 2000). "Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms". The Journal of Cell Biology. 149 (4): 835–50. doi:10.1083/jcb.149.4.835. PMC 2174574. PMID 10811825.
• Fontoura BM, Blobel G, Yaseen NR (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". The Journal of Biological Chemistry. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.
• Freire J, Covelo G, Sarandeses C, Díaz-Jullien C, Freire M (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochemistry and Cell Biology. 79 (2): 123–31. doi:10.1139/bcb-79-2-123. PMID 11310559.
• Renault L, Kuhlmann J, Henkel A, Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. PMID 11336674.
• Nemergut ME, Mizzen CA, Stukenberg T, Allis CD, Macara IG (May 2001). "Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B". Science. 292 (5521): 1540–3. Bibcode:2001Sci...292.1540N. doi:10.1126/science.292.5521.1540. PMID 11375490.
• Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". The Journal of Biological Chemistry. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. PMID 11932251.