RCP9

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.[5][6][7][8]

CRCP
Identifiers
Aliases	CRCP, CGRP-RCP, CGRPRCP, RCP, RCP9, CGRP receptor component, RPC9, POLR3I, POLR3J, C17
External IDs	OMIM: 606121 MGI: 1100818 HomoloGene: 40587 GeneCards: CRCP
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.21 Start 66,114,604 bp[1] End 66,154,568 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 130,029,290 bp[2] End 130,060,789 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • RNA polymerase III activity • DNA-directed 5'-3' RNA polymerase activity • GO:0001948 protein binding • catalytic activity • calcitonin gene-related peptide receptor activity Cellular component • cytosol • membrane • cell membrane • nucleoplasm • Acrosome • DNA polymerase III complex • cell nucleus • DNA-directed RNA polymerase III complex • nuclear DNA-directed RNA polymerase complex • RNA polymerase complex Biological process • immune system process • cell metabolism • defense response to virus • neuropeptide signaling pathway • transcription from RNA polymerase III promoter • innate immune system • DNA-templated transcription, initiation • transcription initiation from RNA polymerase III promoter • positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27297	12909
Ensembl	ENSG00000241258	ENSMUSG00000025532
UniProt	O75575	O35427
RefSeq (mRNA)	NM_001040647 NM_001040648 NM_001142414 NM_014478	NM_007761
RefSeq (protein)	NP_001035737 NP_001035738 NP_001135886 NP_055293	NP_031787
Location (UCSC)	Chr 7: 66.11 – 66.15 Mb	Chr 5: 130.03 – 130.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000241258 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025532 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi:10.1073/pnas.93.8.3455. PMC 39630. PMID 8622957.
6. Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi:10.1210/en.140.3.1459. PMID 10067875.
7. Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662. PMID 12482973.
8. "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".

Further reading

• Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6): 263–9. doi:10.1016/s1043-2760(02)00563-5. PMID 12128288. S2CID 28476322.
• Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. Chem. 275 (40): 31438–43. doi:10.1074/jbc.M005604200. PMID 10903324.
• Prado MA, Evans-Bain B, Oliver KR, Dickerson IM (2002). "The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773–81. doi:10.1016/S0196-9781(01)00517-4. PMID 11754963. S2CID 37139980.
• Moreno MJ, Terrón JA, Stanimirovic DB, et al. (2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture". Neuropharmacology. 42 (2): 270–80. doi:10.1016/S0028-3908(01)00176-9. PMID 11804624. S2CID 45479910.
• Harzenetter MD, Keller U, Beer S, et al. (2002). "Regulation and function of the CGRP receptor complex in human granulopoiesis". Exp. Hematol. 30 (4): 306–12. doi:10.1016/S0301-472X(02)00772-5. PMID 11937264.
• Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hasbak P, Saetrum Opgaard O, Eskesen K, et al. (2003). "Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist". J. Pharmacol. Exp. Ther. 304 (1): 326–33. doi:10.1124/jpet.102.037754. PMID 12490608. S2CID 14045615.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Zuccarello D, Morini E, Douzgou S, et al. (2005). "Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism". J. Endocrinol. Invest. 27 (8): 760–4. doi:10.1007/bf03347519. PMID 15636430. S2CID 19253890.
• Krämer HH, Schmidt K, Leis S, et al. (2006). "Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin". Peptides. 27 (4): 917–20. doi:10.1016/j.peptides.2005.08.007. PMID 16406141. S2CID 24455456.