RECQL5

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.[5][6]

RECQL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BK0, 5LB8, 5LB5, 5LBA, 5LB3
Identifiers
Aliases	RECQL5, RECQ5, RecQ like helicase 5
External IDs	OMIM: 603781 MGI: 2156841 HomoloGene: 31232 GeneCards: RECQL5
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,626,845 bp[1] End 75,667,189 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,892,595 bp[2] End 115,933,477 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA polymerase II core binding • nucleotide binding • GO:0008026 helicase activity • GO:0004003 DNA helicase activity • nucleic acid binding • hydrolase activity • ATP binding • DNA binding • GO:0043140 3'-5' DNA helicase activity • GO:1990163 four-way junction helicase activity • GO:0001948 protein binding • identical protein binding Cellular component • DNA-directed RNA polymerase II, holoenzyme • nucleoplasm • cell nucleus • chromosome • cytoplasm • cytosol Biological process • DNA recombination • DNA metabolic process • negative regulation of transcription elongation from RNA polymerase II promoter • cellular response to DNA damage stimulus • cell division • chromosome separation • DNA replication • cell cycle • DNA repair • DNA duplex unwinding • double-strand break repair via homologous recombination • cellular response to drug • cellular response to camptothecin • replication-born double-strand break repair via sister chromatid exchange • negative regulation of double-strand break repair via homologous recombination • GO:0007067 mitotic cell cycle • mitotic sister chromatid segregation • response to X-ray • negative regulation of mitotic cell cycle • DNA unwinding involved in DNA replication • metabolism Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9400	170472
Ensembl	ENSG00000108469	ENSMUSG00000020752
UniProt	O94762	Q8VID5
RefSeq (mRNA)	NM_001003715 NM_001003716 NM_004259	NM_130454
RefSeq (protein)	NP_001003715 NP_001003716 NP_004250	NP_569721
Location (UCSC)	Chr 17: 75.63 – 75.67 Mb	Chr 11: 115.89 – 115.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RECQL5 has been shown to interact with EEF1G.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000108469 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020752 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics. 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.
6. "Entrez Gene: RECQL5 RecQ protein-like 5".
7. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

Further reading

• Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS (Sep 1999). "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing". Nucleic Acids Research. 27 (18): 3762–9. doi:10.1093/nar/27.18.3762. PMC 148633. PMID 10471747.
• Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (Apr 2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta". Nucleic Acids Research. 28 (7): 1647–55. doi:10.1093/nar/28.7.1647. PMC 102787. PMID 10710432.
• Garcia PL, Liu Y, Jiricny J, West SC, Janscak P (Jul 2004). "Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide". The EMBO Journal. 23 (14): 2882–91. doi:10.1038/sj.emboj.7600301. PMC 514958. PMID 15241474.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G (May 2005). "Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers". Molecular and Cellular Biology. 25 (9): 3431–42. doi:10.1128/MCB.25.9.3431-3442.2005. PMC 1084310. PMID 15831450.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P (2006). "Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork". Nucleic Acids Research. 34 (18): 5217–31. doi:10.1093/nar/gkl677. PMC 1635296. PMID 17003056.
• Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G (Dec 2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments". Genes & Development. 21 (23): 3073–84. doi:10.1101/gad.1609107. PMC 2081974. PMID 18003859.