RGPD5

RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene.[5][6][7]

RGPD5
Identifiers
AliasesRGPD5, BS-63, BS63, HEL161, RGP5, RANBP2-like and GRIP domain containing 5, RANBP2 like and GRIP domain containing 5
External IDsOMIM: 612708 MGI: 894323 HomoloGene: 87808 GeneCards: RGPD5
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q13Start109,792,758 bp[1]
End109,857,705 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84220

19386

Ensembl

ENSG00000015568

ENSMUSG00000003226

UniProt

Q99666

Q9ERU9

RefSeq (mRNA)

NM_005054
NM_032260

NM_011240

RefSeq (protein)

NP_005045
NP_115636

NP_035370

Location (UCSC)Chr 2: 109.79 – 109.86 MbChr 10: 58.45 – 58.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.[7]

Interactions

RGPD5 has been shown to interact with Transportin 1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000015568 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003226 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E, Bork P (March 2005). "Complex genomic rearrangements lead to novel primate gene function". Genome Research. 15 (3): 343–51. doi:10.1101/gr.3266405. PMC 551560. PMID 15710750.
  6. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, et al. (April 2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  7. "Entrez Gene: RGPD5 RANBP2-like and GRIP domain containing 5".
  8. Cai Y, Miao SY, Wang LF (October 2001). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 23 (5): 462–6. PMID 12905863.

Further reading


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