RIOX1

Ribosomal oxygenase 1 is a protein that in humans is encoded by the RIOX1 gene.[5]

RIOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CCJ, 4CCK, 4CCM, 4CCN, 4CCO, 4DIQ, 4E4H, 4Y4R, 4Y33, 4Y3O
Identifiers
Aliases	RIOX1, MAPJD, NO66, ROX, hsNO66, URLC2, C14orf169, chromosome 14 open reading frame 169, ribosomal oxygenase 1, JMJD9
External IDs	OMIM: 611919 MGI: 1919202 HomoloGene: 11366 GeneCards: RIOX1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 73,490,933 bp[1] End 73,493,394 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 83,950,608 bp[2] End 83,952,951 bp[2]
Gene ontology Molecular function • oxidoreductase activity • GO:0001948 protein binding • dioxygenase activity • metal ion binding • histone demethylase activity (H3-K4 specific) • histone demethylase activity (H3-K36 specific) • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • iron ion binding Cellular component • nucleoplasm • cell nucleus • nucleolus Biological process • regulation of transcription, DNA-templated • oxidation-reduction process • transcription, DNA-templated • histone H3-K4 demethylation • histone H3-K36 demethylation • chromatin remodeling • negative regulation of transcription, DNA-templated • negative regulation of osteoblast differentiation • peptidyl-arginine hydroxylation • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79697	71952
Ensembl	ENSG00000170468	ENSMUSG00000046791
UniProt	Q9H6W3	Q9JJF3
RefSeq (mRNA)	NM_024644	NM_023633
RefSeq (protein)	NP_078920	NP_076122
Location (UCSC)	Chr 14: 73.49 – 73.49 Mb	Chr 12: 83.95 – 83.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000170468 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046791 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Chromosome 14 open reading frame 169". Retrieved 2016-04-09.

Further reading

• Eilbracht J, Reichenzeller M, Hergt M, Schnölzer M, Heid H, Stöhr M, Franke WW, Schmidt-Zachmann MS (2004). "NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin". Mol. Biol. Cell. 15 (4): 1816–32. doi:10.1091/mbc.E03-08-0623. PMC 379278. PMID 14742713.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ribosomal oxygenase 1 (RIOX1)