ROBO2

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.[5][6]

ROBO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEM, 1UJT, 2EDJ
Identifiers
Aliases	ROBO2, SAX3, roundabout guidance receptor 2
External IDs	OMIM: 602431 MGI: 1890110 HomoloGene: 43188 GeneCards: ROBO2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p12.3 Start 75,906,695 bp[1] End 77,649,964 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.1 Start 73,891,839 bp[2] End 74,411,825 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding • axon guidance receptor activity Cellular component • integral component of membrane • membrane • cell surface • axolemma • extracellular exosome • cell membrane Biological process • cell differentiation • ureteric bud development • kidney development • negative regulation of synapse assembly • Roundabout signaling pathway • positive regulation of axonogenesis • nervous system development • multicellular organism development • chemotaxis • central nervous system development • cellular response to hormone stimulus • olfactory bulb interneuron development • apoptotic process involved in luteolysis • negative regulation of negative chemotaxis • axon midline choice point recognition • metanephros development • homophilic cell adhesion via plasma membrane adhesion molecules • retinal ganglion cell axon guidance • brain development • spinal cord development • axon guidance • outflow tract septum morphogenesis • aortic valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion formation • positive regulation of Notch signaling pathway involved in heart induction • aorta development • ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6092	268902
Ensembl	ENSG00000185008	ENSMUSG00000052516
UniProt	Q9HCK4	Q7TPD3
RefSeq (mRNA)	NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942 NM_001378190 NM_001378191 NM_001378192 NM_001378193 NM_001378194 NM_001378195 NM_001378196 NM_001378197 NM_001378198 NM_001378199 NM_001378200 NM_001378201 NM_001378202 NM_001378203	NM_175549 NM_001358490 NM_001358491 NM_001358492 NM_001358493 NM_001358494
RefSeq (protein)	NP_001122401 NP_001276968 NP_001276969 NP_001276994 NP_002933 NP_001365119 NP_001365120 NP_001365121 NP_001365122 NP_001365123 NP_001365124 NP_001365125 NP_001365126 NP_001365127 NP_001365128 NP_001365129 NP_001365130 NP_001365131 NP_001365132	n/a
Location (UCSC)	Chr 3: 75.91 – 77.65 Mb	Chr 16: 73.89 – 74.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000185008 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052516 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (Feb 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell. 92 (2): 205–15. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045. S2CID 2036419.
6. "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)".

Further reading

• Brose K, Bland KS, Wang KH, et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268. S2CID 16301178.
• Nguyen Ba-Charvet KT, Brose K, Marillat V, et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons". Neuron. 22 (3): 463–73. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527. S2CID 18663762.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Nguyen Ba-Charvet KT, Brose K, Ma L, et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". J. Neurosci. 21 (12): 4281–9. doi:10.1523/JNEUROSCI.21-12-04281.2001. PMC 6762758. PMID 11404413.
• Marillat V, Cases O, Nguyen-Ba-Charvet KT, et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain". J. Comp. Neurol. 442 (2): 130–55. doi:10.1002/cne.10068. PMID 11754167. S2CID 24164570.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hivert B, Liu Z, Chuang CY, et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth". Mol. Cell. Neurosci. 21 (4): 534–45. doi:10.1006/mcne.2002.1193. PMID 12504588. S2CID 19664833.
• Grieshammer U, Le M, Plump AS, et al. (2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site". Dev. Cell. 6 (5): 709–17. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yue Y, Grossmann B, Galetzka D, et al. (2007). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice". Genomics. 88 (6): 772–8. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
• Lu W, van Eerde AM, Fan X, et al. (2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux". Am. J. Hum. Genet. 80 (4): 616–32. doi:10.1086/512735. PMC 1852714. PMID 17357069.