ROCK2

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [5]Fasudil is an inhibitor of ROCK protein.

ROCK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L6Q, 4WOT
Identifiers
Aliases	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDs	OMIM: 604002 MGI: 107926 HomoloGene: 21010 GeneCards: ROCK2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 11,179,759 bp[1] End 11,348,330 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 16,894,895 bp[2] End 16,987,823 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • structural molecule activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • Rho GTPase binding • ATP binding • Rho-dependent protein serine/threonine kinase activity • RNA binding • tau protein binding • tau-protein kinase activity • GTP-Rho binding Cellular component • cytoplasm • centrosome • membrane • cell membrane • microtubule organizing center • cytoplasmic ribonucleoprotein granule • cytoskeleton • cell nucleus • cytosol • intracellular Biological process • smooth muscle contraction • positive regulation of protein phosphorylation • GO:0007243 intracellular signal transduction • regulation of actin cytoskeleton organization • centrosome duplication • phosphorylation • rhythmic process • ephrin receptor signaling pathway • cellular response to testosterone stimulus • cytokinesis • positive regulation of centrosome duplication • regulation of stress fiber assembly • regulation of cell motility • positive regulation of endothelial cell migration • protein phosphorylation • negative regulation of bicellular tight junction assembly • vascular endothelial growth factor receptor signaling pathway • positive regulation of gene expression • regulation of cell adhesion • regulation of circadian rhythm • Rho protein signal transduction • regulation of focal adhesion assembly • negative regulation of angiogenesis • regulation of keratinocyte differentiation • negative regulation of myosin-light-chain-phosphatase activity • I-kappaB kinase/NF-kappaB signaling • regulation of establishment of cell polarity • GO:0033109 cortical actin cytoskeleton organization • regulation of establishment of endothelial barrier • actin cytoskeleton organization • protein localization to plasma membrane • G-protein coupled receptor signaling pathway • aortic valve morphogenesis • positive regulation of cardiac muscle hypertrophy • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • positive regulation of cell migration • positive regulation of connective tissue growth factor production • positive regulation of MAPK cascade • regulation of protein metabolic process • positive regulation of stress fiber assembly • negative regulation of biomineral tissue development • response to transforming growth factor beta • positive regulation of fibroblast growth factor production • regulation of angiotensin-activated signaling pathway • negative regulation of protein localization to lysosome • positive regulation of amyloid-beta formation • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • positive regulation of protein localization to early endosome • positive regulation of amyloid precursor protein catabolic process • positive regulation of connective tissue replacement • response to angiotensin • response to ischemia • negative regulation of gene expression • regulation of neurological system process • negative regulation of nitric oxide biosynthetic process • mRNA destabilization • regulation of blood vessel diameter • regulation of cellular response to hypoxia • cellular response to acetylcholine • mitotic cytokinesis • actomyosin structure organization • embryonic morphogenesis • regulation of cell junction assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9475	19878
Ensembl	ENSG00000134318	ENSMUSG00000020580
UniProt	O75116	P70336
RefSeq (mRNA)	NM_004850 NM_001321643	NM_009072
RefSeq (protein)	NP_001308572 NP_004841	NP_033098
Location (UCSC)	Chr 2: 11.18 – 11.35 Mb	Chr 12: 16.89 – 16.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

References

1. GRCh38: Ensembl release 89: ENSG00000134318 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020580 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

Further reading

• Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

• Overview of all the structural information available in the PDB for UniProt: O75116 (Human Rho-associated protein kinase 2 (ROCK2)) at the PDBe-KB.