RREB1

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.[5][6][7]

RREB1
Identifiers
Aliases	RREB1, FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1
External IDs	OMIM: 602209 MGI: 2443664 HomoloGene: 2218 GeneCards: RREB1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.3 Start 7,107,597 bp[1] End 7,251,980 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.3 Start 37,778,400 bp[2] End 37,952,005 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • metal ion binding • nucleic acid binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nuclear body • extracellular exosome • fibrillar center • cell nucleus • cytoplasm • nuclear speck Biological process • positive regulation of mammary gland epithelial cell proliferation • positive regulation of lamellipodium morphogenesis • regulation of transcription, DNA-templated • positive regulation of epithelial cell migration • transcription from RNA polymerase II promoter • transcription, DNA-templated • multicellular organism development • positive regulation of transcription, DNA-templated • positive regulation of substrate adhesion-dependent cell spreading • Ras protein signal transduction • negative regulation of transcription, DNA-templated • positive regulation of wound healing, spreading of epidermal cells • negative regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6239	68750
Ensembl	ENSG00000124782	ENSMUSG00000039087
UniProt	Q92766	Q3UH06
RefSeq (mRNA)	NM_001003698 NM_001003699 NM_001003700 NM_001168344 NM_002955	NM_001013392 NM_001039188 NM_001177868 NM_001177869 NM_026830
RefSeq (protein)	NP_001003698 NP_001003699 NP_001003700 NP_001161816 NP_001003698.1 NP_001161816.1	NP_001034277 NP_001171339 NP_001171340 NP_081106
Location (UCSC)	Chr 6: 7.11 – 7.25 Mb	Chr 13: 37.78 – 37.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000124782 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039087 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi:10.1006/geno.1997.5001. PMID 9367691.
6. Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. doi:10.1016/j.cub.2008.03.024. PMID 18394891. S2CID 17251337.
7. "Entrez Gene: RREB1 ras responsive element binding protein 1".
8. Bonomo, J. A.; Guan, M; Ng, M. C.; Palmer, N. D.; Hicks, P. J.; Keaton, J. M.; Lea, J. P.; Langefeld, C. D.; Freedman, B. I.; Bowden, D. W. (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC 4240197. PMID 25027322.

Further reading

• Thiagalingam A, De Bustros A, Borges M, et al. (1996). "RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas". Mol. Cell. Biol. 16 (10): 5335–45. doi:10.1128/mcb.16.10.5335. PMC 231532. PMID 8816445.
• Fujimoto-Nishiyama A, Ishii S, Matsuda S, et al. (1997). "A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies". Gene. 195 (2): 267–275. doi:10.1016/S0378-1119(97)00172-8. PMID 9305772.
• Zhang L, Zhao J, Edenberg HJ (1999). "A human Raf-responsive zinc-finger protein that binds to divergent sequences". Nucleic Acids Res. 27 (14): 2947–2956. doi:10.1093/nar/27.14.2947. PMC 148511. PMID 10390538.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ray SK, Nishitani J, Petry MW, et al. (2003). "Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1". Mol. Cell. Biol. 23 (1): 259–271. doi:10.1128/MCB.23.1.259-271.2003. PMC 140679. PMID 12482979.
• Zhang S, Qian X, Redman C, et al. (2003). "p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB". Oncogene. 22 (15): 2285–2295. doi:10.1038/sj.onc.1206257. PMID 12700664.
• Shi Y, Sawada J, Sui G, et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–738. Bibcode:2003Natur.422..735S. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Date S, Nibu Y, Yanai K, et al. (2005). "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene". Int. J. Mol. Med. 13 (5): 637–42. doi:10.3892/ijmm.13.5.637. PMID 15067362.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.