rRNA (adenine-N6-)-methyltransferase
In enzymology, a rRNA (adenine-N6-)-methyltransferase (EC 2.1.1.48) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + rRNA S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine
| rRNA (adenine-N6-)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.48 | ||||||||
| CAS number | 9076-81-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing N6-methyladenine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase. Other names in common use include ribosomal ribonucleate adenine 6-methyltransferase, gene ksgA methyltransferase, ribonucleic acid-adenine (N6) methylase, ErmC 23S rRNA methyltransferase, and S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1QAM, 1QAN, 1QAO, 1QAQ, 1YUB, and 2ERC.
References
- Sipe JE, Anderson WM, Remy CN, Love SH (1972). "Characterization of S-adenosylmethionine: ribosomal ribonucleic acid-adenine (N 6 -) methyltransferase of Escherichia coli strain B". J. Bacteriol. 110 (1): 81–91. doi:10.1128/JB.110.1.81-91.1972. PMC 247381. PMID 4622906.