RUFY1

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene.[5][6] It is named after the RUN and FYVE domains it contains.

RUFY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YQM, 2YW8
Identifiers
Aliases	RUFY1, RABIP4, ZFYVE12, RUN and FYVE domain containing 1
External IDs	OMIM: 610327 MGI: 2429762 HomoloGene: 23522 GeneCards: RUFY1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 179,550,554 bp[1] End 179,610,012 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 50,389,286 bp[2] End 50,431,125 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • lipid binding • SH3 domain binding • SH2 domain binding Cellular component • intracellular membrane-bounded organelle • membrane • cytoplasm • cytosol • nuclear speck • early endosome membrane • endosome • cell nucleus Biological process • protein transport • endocytosis • phosphatidylinositol biosynthetic process • regulation of endocytosis • small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80230	216724
Ensembl	ENSG00000284260 ENSG00000176783	ENSMUSG00000020375
UniProt	Q96T51	Q8BIJ7
RefSeq (mRNA)	NM_001040451 NM_001040452 NM_025158	NM_172557
RefSeq (protein)	NP_001035541 NP_001035542 NP_079434	NP_766145
Location (UCSC)	Chr 5: 179.55 – 179.61 Mb	Chr 11: 50.39 – 50.43 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RUFY1 has been shown to interact with BMX.[5]

References

1. ENSG00000176783 GRCh38: Ensembl release 89: ENSG00000284260, ENSG00000176783 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020375 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
6. "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

Further reading

• Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
• Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell. 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC 329268. PMID 14617813.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.